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Article
Open AccessMetastatic lymph node targeted CTLA4 blockade: a potent intervention for local and distant metastases with minimal ICI-induced pneumonia
Immune checkpoint blockade (ICB) elicits a strong and durable therapeutic response, but its application is limited by disparate responses and its associated immune-related adverse events (irAEs). Previously, i...
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Article
Perfusion defects in non-enlarged metastatic lymph nodes using vessel wall magnetic resonance imaging: Detection performance and diagnostic value
A perfusion defect (PD) in non-enlarged lymph nodes (LNs) of oral squamous cell carcinoma (OSCC) is the most reliable radiological criterion for the diagnosis of metastasis. However, conventional contrast-enha...
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Article
Characterizing perfusion defects in metastatic lymph nodes at an early stage using high-frequency ultrasound and micro-CT imaging
A perfusion defect in a metastatic lymph node (LN) can be visualized as a localized area of low contrast on contrast-enhanced CT, MRI or ultrasound images. Hypotheses for perfusion defects include abnormal hem...
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Article
Open AccessAnalysis of tumor vascularization in a mouse model of metastatic lung cancer
Therapies targeting tumor vasculature would improve the treatment of lung metastasis, although the early changes in vascular structure are incompletely understood. Here, we show that obstructive metastatic foc...
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Article
Imaging of the Mouse Lymphatic Sinus during Early Stage Lymph Node Metastasis Using Intranodal Lymphangiography with X-ray Micro-computed Tomography
Lymph node (LN) metastasis is detected prior to distant metastasis in many types of cancer. Detecting early stage LN metastasis can improve treatment outcomes. However, there are few clinical imaging modalitie...
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Article
Open AccessUse of a Lymphatic Drug Delivery System and Sonoporation to Target Malignant Metastatic Breast Cancer Cells Proliferating in the Marginal Sinuses
Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesion...
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Article
Open AccessThe effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed destructive arthritis and enthesitis
McH-lpr/lpr-RA1 mice are a new strain of mice which spontaneously develop destructive arthritis and enthesitis in the ankle. There is no published data that drug treatment has been trialed on these mice. This ...
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Article
Why does the Quiet Eye improve aiming accuracy? Testing a motor preparation hypothesis with brain potential
The purpose of the present study was to determine whether the Quiet Eye (QE) acquired over time is associated with motor preparation processes by using movement-related cortical potentials (MRCPs). Eighteen ma...
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Article
Open AccessEvaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes
Surgical removal of primary tumors can promote the incidence of tumor metastasis. However, molecular mechanisms underlying this process remain unclear.
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Article
Open AccessA novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy
Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the lymphatic network can achieve mor...
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Article
Open AccessNew concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network
Intravenous chemotherapy has poor access to metastatic lymph nodes (LNs) and is limited by short-lived drug concentrations. Here, we describe the administration of chemotherapy via the lymphatic network as a n...
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Article
Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light with controlled surface cooling
Photothermal therapy (PTT) using near-infrared (NIR) laser light and gold nanorods (GNRs) shows promise as a novel cancer treatment modality. However, the laser intensity required to destroy tumor cells locate...
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Article
Color perception is impaired in baseball batters while performing an interceptive action
In order to test the theoretical idea that experts rely more on the dorsal stream than the ventral stream during interceptive action for the interception of a moving target, the present study investigates the ...
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Article
Effects of sport expertise on representational momentum during timing control
Sports involving fast visual perception require players to compensate for delays in neural processing of visual information. Memory for the final position of a moving object is distorted forward along its path...
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Article
Fast-ball sports experts depend on an inhibitory strategy to reprogram their movement timing
The purpose of our study was to clarify whether an inhibitory strategy is used for reprogramming of movement timing by experts in fast-ball sports when they correct their movement timing due to unexpected envi...
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Article
Flower color alteration in the liliaceous ornamental Tricyrtis sp. by RNA interference-mediated suppression of the chalcone synthase gene
Chalcone synthase (CHS) is the key enzyme in an early stage of the flavonoid biosynthetic pathway. In the present study, a full-length cDNA clone for CHS was isolated from flower tepals of the liliaceous ornam...
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Article
Knee extensor strength is associated with Mini-Mental State Examination scores in elderly men
The present study examined whether the strength capability of knee extensor muscles is associated with global cognitive function, assessed by Mini-Mental State Examination (MMSE), in non-disabled elderly men. ...
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Chapter and Conference Paper
Epigallocatechin Gallate Disturbs Thymidine Glycol Formation Induced by Oxidative Stress in Sjögren’s Syndrome-Like Autoimmune Sialadenitis of MRL/lpr Mice
In this study, we administered EGCG to MRL/lpr mice from age of 8–16 weeks for 57 days, and thereafter examined immunohistochemically the expression of thymidine glycol (TG), heme oxygenase-1 (HO-1) and ssDNA ...
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Article
Promotion of somatic embryo production from embryogenic calluses of monocotyledonous and dicotyledonous plants by heavy-ion beam irradiation
Effect of heavy-ion beam irradiation on the growth and development of embryogenic calluses was examined in the liliaceous monocotyledon Tricyrtis hirta and the umbelliferous dicotyledon Daucus carota. Embryogenic...
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Chapter and Conference Paper
Immunohistochemical localization of CD134 ligand, CD137 ligand, GITR ligand, and BAFF in Sjögren’s syndrome-like autoimmune sialadenitis of MRL/lpr mice
Although the mechanism provoking Sjören’s syndrome has been extensively studied, the pathogenesis remains obscure. We examined immunohistochemically the expression of CD134 ligand, CD137 ligand, glucocorticoid...
