32 Result(s)

Article

Variability in the prevalence of depression among adults with chronic pain: UK Biobank analysis through clinical prediction models

The prevalence of depression among people with chronic pain remains unclear due to the heterogeneity of study samples and definitions of depression. We aimed to identify sources of variation in the prevalence ...

Lingxiao Chen, Claire E Ashton-James, Baoyi Shi, Maja R Radojčić… in BMC Medicine (2024)

Article

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

To date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be elucidated. Here, Piezo1 channel was identified as a key iron transporter in response ...

Ziqian **ang, Pengfei Zhang, Chunwang Jia, Rongkun Xu, Dingren Cao… in Bone Research (2024)

Article

A spine segmentation method based on scene aware fusion network

Intervertebral disc herniation, degenerative lumbar spinal stenosis, and other lumbar spine diseases can occur across most age groups. MRI examination is the most commonly used detection method for lumbar spin...

Elzat Elham Yilizati-Yilihamu, **tao Yang, Zimeng Yang, Feihao Rong… in BMC Neuroscience (2023)

Article

Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice

Spinal cord injury (SCI) could lead to severe disabilities in motor and sensory functions, and cause a heavy burden on patient physiology and psychology due to lack of specific repair measures so far. ANXA7 is...

Na Li, Lu Chen, **aoqing Zhao, Chi Gu, Yong Chang, Shiqing Feng in Cell Death Discovery (2023)

Article

Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Preinjury of peripheral nerves triggers dorsal root ganglia (DRG) axon regeneration, a biological change that is more pronounced in young mice than in old mice, but the complex mechanism has not been clearly e...

**aoxiong Wang, Wenxiang Li, Jian** Zhang, **ze Li… in Journal of Translational Medicine (2023)

Article

N¹-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction

N¹-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress. However, the charact....

Zhangyang Qi, Chi Zhang, Huan Jian, Mengfan Hou, Yongfu Lou… in Cell Death Discovery (2023)

Article

Ang-(1–7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarization

Inflammatory response is an essential part of secondary injury after spinal cord injury (SCI). During this period, the injury may be exacerbated through the release of a large number of inflammatory factors an...

Guang** Gu, Bin Zhu, Jie Ren, **aomeng Song, Baoyou Fan, Han Ding… in Cell & Bioscience (2023)

Article

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury

Macrophage/microglia polarization acts as an important part in regulating inflammatory responses in spinal cord injury (SCI). However, the regulation of inflammation of Schwann cell-derived exosomes (SCDEs) fo...

Jie Ren, Bin Zhu, Guang** Gu, Wencan Zhang, Jun** Li, Hongda Wang… in Cell Death & Disease (2023)

Article

Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices

Zwitterionic hydrogels exhibit eminent nonfouling and hemocompatibility. Several key challenges hinder their application as coating materials for blood-contacting biomedical devices, including weak mechanical ...

Mengmeng Yao, Zhijian Wei, Jun** Li, Zhicheng Guo, Zhuojun Yan… in Nature Communications (2022)

Article

Retraction Note to: Inhibition of TGF-β repairs spinal cord injury by attenuating EphrinB2 expressing through inducing miR-484 from fibroblast

Dayu Pan, Fuhan Yang, Shibo Zhu, Yong** Li, Guangzhi Ning… in Cell Death Discovery (2022)

Article

Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats

Nafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease inhibitor that exerts anti-neuroinflammation and neuroprotective effects following rat spinal cord injury (SCI). However, clinical transl...

Chenxi Zhao, Tiangang Zhou, **aoqing Zhao, Yilin Pang… in Journal of Neuroinflammation (2022)

Article

Progression in translational research on spinal cord injury based on microenvironment imbalance

Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been reco...

Baoyou Fan, Zhijian Wei, Shiqing Feng in Bone Research (2022)

Article

Autophagy induced by Schwann cell-derived exosomes promotes recovery after spinal cord injury in rats

Spinal cord injury (SCI) is catastrophic to humans and society. However, there is currently no effective treatment for SCI. Autophagy is known to serve critical roles in both the physiological and pathological...

Dayu Pan, Shibo Zhu, Weixin Zhang, Zhijian Wei, Fuhan Yang… in Biotechnology Letters (2022)

Article

RETRACTED ARTICLE: Inhibition of TGF-β repairs spinal cord injury by attenuating EphrinB2 expressing through inducing miR-484 from fibroblast

Spinal cord injury (SCI) can lead to severe loss of motor and sensory function with high disability and mortality. The effective treatment of SCI remains unknown. Here we find systemic injection of TGF-β neutr...

Dayu Pan, Fuhan Yang, Shibo Zhu, Yong** Li, Guangzhi Ning… in Cell Death Discovery (2021)

Article

Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury

Traumatic spinal cord injury (SCI) is a severely disabling disease that leads to loss of sensation, motor, and autonomic function. As exosomes have great potential in diagnosis, prognosis, and treatment of SCI...

Dayu Pan, Yong** Li, Fuhan Yang, Zenghui Lv, Shibo Zhu… in Journal of Neuroinflammation (2021)

Article

Does surgical treatment produce better outcomes than conservative treatment for acute primary patellar dislocations? A meta-analysis of 10 randomized controlled trials

The objective of this study was to conduct the latest meta-analysis of randomized controlled trials (RCTs) that compare clinical results between surgery and conservative therapy of acute primary patellar dislo...

Xuewu **ng, Hongyu Shi, Shiqing Feng in Journal of Orthopaedic Surgery and Research (2020)