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Article
Open AccessExploration of programmed cell death-associated characteristics and immune infiltration in neonatal sepsis: new insights from bioinformatics analysis and machine learning
Neonatal sepsis, a perilous medical situation, is typified by the malfunction of organs and serves as the primary reason for neonatal mortality. Nevertheless, the mechanisms underlying newborn sepsis remain am...
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Article
Inverse problem for a random Schrödinger equation with unknown source and potential
In this paper, we study an inverse scattering problem associated with the time-harmonic Schrödinger equation where both the potential and the source terms are unknown. The source term is assumed to be a genera...
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Article
Open AccessMultimodal brain imaging effect of “Adjust Zang-fu and Arouse Spirit” electroacupuncture on diabetic cognitive impairment: study protocol of a randomized, sham-controlled pilot trial
Diabetic cognitive impairment (DCI) is a serious chronic complication caused by diabetes. The pathogenesis of DCI is complex, but brain nerve injury and brain nerve cell apoptosis are important pathological ch...
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Article
Open AccessMultimodal cerebral imaging study on the effects of “Adjust Zang Dredge Meridian” electroacupuncture on cerebral central sensitization in PDPN patients: a study protocol for a sham-controlled, randomized trial
Painful diabetic peripheral neuropathy (PDPN) has a great impact on an individual’s quality of life. The current researchers’ previous trial suggested that acupuncture was a promising adjunctive treatment for ...
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Article
Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective against non-small cell lung cancer (NSCLC) with EGFR-activating mutations. The mechanisms underlying EGFR-TKI resistance are n...
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Article
Determining a Random Schrödinger Operator: Both Potential and Source are Random
We study an inverse scattering problem associated with a Schrödinger system where both the potential and source terms are random and unknown. The well-posedness of the forward scattering problem is first estab...
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Article
Open AccessPositive solutions to second-order singular nonlocal problems: existence and sharp conditions
In this paper we consider sharp conditions on ω and f for the existence of ...
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Article
Petrographic analysis of pottery from the Haminmangha site (2010–2011), Inner Mongolia
The Haminmangha site is an important prehistoric settlement site in the Khorchin area of Inner Mongolia. Due to its unique combination of pottery and a distinctive regional decoration called the “pitting patte...
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Article
Open AccessA network-based predictive gene-expression signature for adjuvant chemotherapy benefit in stage II colorectal cancer
The clinical benefit of adjuvant chemotherapy for stage II colorectal cancer (CRC) is controversial. This study aimed to explore novel gene signature to predict outcome benefit of postoperative 5-Fu-based ther...
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Article
Open AccessTargeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter
Dopamine transporter (DAT) has been shown to accumulate in filopodia in neurons and non-neuronal cells. To examine the mechanisms of DAT filopodial targeting, we used quantitative live-cell fluorescence micros...
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Article
Open AccessA retrospective analysis of characteristics of visual field damage in patients with Leber’s hereditary optic neuropathy
The objective of this study is to investigate the characteristics and the evolution of visual field damage caused by Leber’s hereditary optic neuropathy (LHON) and to provide clinical data for the diagnosis of...
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Article
Open AccessAtractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro
TLR4/MD-2 complex-mediated MyD88-dependent activation of NF-κB and Akt promotes tumor-associated immunosuppression in epithelial ovarian cancer (EOC) via induction of immunesuppressive cytokines and indoleamin...
