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  1. No Access

    Article

    A phase 2 study of axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma in Japan: 1-year follow-up and biomarker analysis

    Axicabtagene ciloleucel (axi-cel) is an autologous, CD19-targeting chimeric antigen receptor T‑cell therapy. We recently reported the 3-month follow-up results of a phase 2, multicenter, open‑label, single-arm...

    Koji Kato, Nobuharu Fujii, Shinichi Makita… in International Journal of Hematology (2023)

  2. Article

    Open Access

    Phase 2 study of axicabtagene ciloleucel in Japanese patients with relapsed or refractory large B-cell lymphoma

    Axicabtagene ciloleucel (axi-cel) is an autologous chimeric antigen receptor T-cell based anti-CD19 therapy. The ZUMA-1 study, multicenter, single-arm, registrational Phase 1/2 study of axi-cel demonstrated hi...

    Koji Kato, Shinichi Makita, Hideki Goto… in International Journal of Clinical Oncology (2022)

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  3. Article

    Open Access

    Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain

    Nearly all bodily processes exhibit circadian rhythmicity. As a consequence, the pharmacokinetic and pharmacodynamic properties of a drug may also vary with time of day. The objective of this study was to inve...

    Laura Kervezee, Robin Hartman, Dirk-Jan van den Berg, Shinji Shimizu… in The AAPS Journal (2014)

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  4. No Access

    Article

    Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model

    We investigated hepatotoxicity induced by ticlopidine (TIC) in glutathione (GSH)-depleted rats by pre-treatment of a well-known GSH synthesis inhibitor, l-buthionine-S,R-sulfoxinine (BSO). Although sole administr...

    Shinji Shimizu, Ryo Atsumi, Tsunenori Nakazawa, Takashi Izumi… in Archives of Toxicology (2011)

  5. No Access

    Article

    Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice

    We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or l-buthionine-S,R-sulfoxinine (BSO), a well-known GSH synthesis inhibito...

    Shinji Shimizu, Ryo Atsumi, Kenichi Itokawa, Masaru Iwasaki… in Archives of Toxicology (2009)

  6. No Access

    Article

    Inhibitory effect of triamcinolone acetonide on corneal neovascularization

    Corneal neovascularization (NV) plays an important role in the pathogenesis of corneal disorders. Recently, triamcinolone acetonide (TA) has been reported as a potential treatment for ocular angiogenesis. Howe...

    Masatoshi Murata, Shinji Shimizu… in Graefe's Archive for Clinical and Experime… (2006)

  7. No Access

    Chapter

    Assessment of Thermophysical Properties at Design Stage of Machine Tool Structure with Thermal Symmetricity

    This paper describes the relationship between thermal behavior and thermophysical properties of cross rail material of double column type machine tools. Assessment is performed to thermophysical properties of ...

    Masayuki Okabe, Haruhisa Sakamoto… in Initiatives of Precision Engineering at th… (2002)

  8. No Access

    Chapter

    Evaluation Method of Thermal Displacement of Machine Tools

    Recently speeding-up in machine tools’ spindles tends to increase greatly thermal displacement of the machine tools. Then the standardization of the measurement and evaluation methods of the thermal displaceme...

    Shinji Shimizu, Noboru Imai in Initiatives of Precision Engineering at th… (2002)