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Article
Open AccessSex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort
Frailty is a common geriatric syndrome related to multiple adverse outcomes. Sex differences in its prevalence and impact on mortality remain incompletely understood.
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Article
Open AccessSex difference in the association of the triglyceride glucose index with obstructive coronary artery disease
Insulin resistance (IR) is associated with cardiovascular disease in non-diabetic patients. The triglyceride-glucose (TyG) index, incorporating serum glucose and insulin concentrations, is a surrogate insulin ...
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Article
Open AccessLong-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression
Long-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) and cardiovascular disease. Caveolae and caveolin-1 (CAV-1) proteins ...
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Article
Open AccessHyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway
Previous studies have revealed associations between hyperuricemia and microvascular diseases, but the association between hyperuricemia and abdominal aortic aneurysm (AAA) remains unclear. The aim of this stud...
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Article
Open AccessmiR-548j-5p regulates angiogenesis in peripheral artery disease
Peripheral artery disease (PAD) is a vascular disease involving diffuse atherosclerosis, and is associated with increased cardiovascular mortality and morbidity. Critical limb ischemia (CLI) is the most severe...
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Article
Open AccessParadox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients
Trimethylamine N-oxide (TMAO) is a microbiota-derived metabolite, which is linked to vascular inflammation and atherosclerosis in cardiovascular (CV) diseases. But its effect in infectious diseases remains unclea...
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Article
Open AccessGender difference in the association between TyG index and subclinical atherosclerosis: results from the I-Lan Longitudinal Aging Study
Insulin resistance (IR) is a known risk factor for cardiovascular disease (CVD) in non-diabetic patients through the association of hyperglycemia or associated metabolic factors. The triglyceride glucose (TyG)...
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Article
Open AccessAssociation between phosphate and long-term outcome in CAD patients underwent coronary intervention
Phosphate has been linked to higher cardiovascular (CV) risk. However, whether phosphate is associated with poor outcomes for patients with coronary artery disease (CAD) after percutaneous coronary interventio...
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Article
Open AccessThe association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients. ...
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Article
Open AccessSitagliptin attenuates arterial calcification by downregulating oxidative stress-induced receptor for advanced glycation end products in LDLR knockout mice
Diabetes is a complex disease characterized by hyperglycemia, dyslipidemia, and insulin resistance. Plasma advanced glycation end products (AGEs) activated the receptor for advanced glycation end products (RAG...
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Article
Open AccessPremorbid β1-selective (but not non-selective) β-blocker exposure reduces intensive care unit mortality among septic patients
β-blockers may protect against catecholaminergic myocardial injury in critically ill patients. Long-term β-blocker users are known to have lower lactate concentrations and favorable sepsis outcomes. However, the ...
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Article
Open AccessFenofibrate attenuates doxorubicin-induced cardiac dysfunction in mice via activating the eNOS/EPC pathway
Endothelial progenitor cells (EPCs) improve endothelial impairment, which in turn restores endothelial function in patients with heart failure (HF). In the present study, we tested whether fenofibrate, with it...
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Article
Open AccessGalectin-1 is associated with the severity of coronary artery disease and adverse cardiovascular events in patients undergoing coronary angiography
Galectin-1, a β-galactoside-binding lectin mediating inflammation and neovascularization, is reported to attenuate ventricular remodeling after myocardial infarction. But its role in stable coronary artery dis...
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Article
Open AccessThe relationship between circulating vitamin D3 and subclinical atherosclerosis in an elderly Asian population
The current evidence regarding the association between vitamin D deficiency and cardiovascular diseases/metabolic disorders is contradictory and inconclusive. In this large-scale observational study, we invest...
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Article
Open AccessLong-Term Cilostazol Treatment and Predictive Factors on Outcomes of Endovascular Intervention in Patients with Diabetes Mellitus and Critical Limb Ischemia
Despite improvements in endovascular interventions and multidisciplinary approaches, improving clinical outcomes and increasing limb salvage have become increasingly challenging. This prospective study investi...
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Article
Open AccessEffects of cardiovascular medications on primary patency of hemodialysis arteriovenous fistula
While the patency of vascular access is essential for hemodialysis patients, optimal pharmaceutical treatment to maintain arteriovenous fistula (AVF) patency remains lacking. As cardiovascular diseases are hig...
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Article
Open AccessAuthor Correction: Serum Activin A Levels and Renal Outcomes After Coronary Angiography
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Fenofibrate Reverses Dysfunction of EPCs Caused by Chronic Heart Failure
The enhanced activity of endothelial progenitor cells (EPCs) by AMP-activated protein kinase (AMPK) agonists might explain the reversal of chronic heart failure (CHF)–mediated endothelial dysfunction. We studi...
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Article
Open AccessSerum Activin A Levels and Renal Outcomes After Coronary Angiography
Prevention for contrast-induced nephropathy (CIN) is limited by the lack of a single predictor. As activin A is upregulated in heart failure and chronic kidney disease, we aimed to clarify the association betw...
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Article
Open AccessInhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance
Recent evidence suggests that enhanced protease-mediated inflammation may promote insulin resistance and result in diabetes. This study tested the hypothesis that serine protease plays a pivotal role in type 2...
