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  1. No Access

    Article

    Lineage-specific Mechanism of Drug and Radiation Resistance in Melanoma Mediated by Tyrosinase-related Protein 2

    A major obstacle in the clinical management of malignant melanoma is its intrinsic resistance to chemotherapy and radiation therapy. Consequently, most patients with melanoma often do not respond to convention...

    Brian J. Pak, Wendy Chu, Shi Jiang Lu, Robert S. Kerbel… in Cancer and Metastasis Reviews (2001)

  2. No Access

    Article

    Tyrosinase-related protein 2 as a mediator of melanoma specific resistance to cis-diamminedichloroplatinum(II): therapeutic implications

    A major obstacle in the systemic treatment of advanced malignant melanoma is its intrinsic resistance to conventionally used chemotherapeutic agents. In order to investigate the mechanisms of this intrinsic re...

    Wendy Chu, Brian J Pak, Maria Rosa Bani, Monika Kapoor, Shi-Jiang Lu, Ami Tamir… in Oncogene (2000)

  3. No Access

    Chapter

    Reactive Metabolites from N-Nitrosamines

    N-Nitrosodialkylamines are metabolically activated by hydroxylation at the carbon atom alpha to the N-nitroso group. Spontaneous cleavage of the C-N bond in the α-hydroxynitrosamine leads to production of an alky...

    Michael C. Archer, Jamie R. Milligan… in Biological Reactive Intermediates IV (1991)