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Article
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including Alzheimer’s disease (AD). We have recently conceptualize...
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Article
Open AccessIdentification of osteoporosis ferroptosis-related markers and potential therapeutic compounds based on bioinformatics methods and molecular docking technology
Osteoporosis (OP) is one of the most common bone diseases worldwide, characterized by low bone mineral density and susceptibility to pathological fractures, especially in postmenopausal women and elderly men. ...
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Article
Open AccessTargeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the spec...
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Article
Open AccessIntracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy.
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Article
Open AccessAspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia
Hyperlipidemia, with an increasing of prevalence, has become one of the common metabolic diseases in companion animal clinic. Aspirin eugenol ester (AEE) is a novel compound that exhibits efficacious anti-hype...
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Article
Open AccessRegulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia
Aspirin eugenol ester (AEE) is a promising drug candidate for treatment of inflammation, pain and fever and prevention of cardiovascular diseases with less side effects. The experiment will be conducted to inv...
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Article
Open AccessPegylated interferon α enhances recovery of memory T cells in e antigen positive chronic hepatitis B patients
Interferons (IFNs) are a group of cytokines commonly used in the clinical treatment of chronic hepatitis B (CHB) patients. Their therapeutic effects are highly correlated with recovery of host antiviral immuni...
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Article
Influences of artificial pre-stressing on ply stresses and tensile properties of Vinylon fibre-reinforced aluminium laminates (VIRALL)
A simple micromechanical model based primarily upon the rule-of-mixtures is developed which allows prediction of the effects of fibre preload on the ply stresses (i.e., the initial residual stresses of fibre, ...
