33 Result(s)

Article

Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy

The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether Nur77 inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not...

Huanying Shi, Lu Chen, Tianxiao Wang, Wenxin Zhang, Jiafeng Liu… in Cell Death Discovery (2024)

Article

Inter- and trans-generational impacts of real-world PM_2.5 exposure on male-specific primary hypogonadism

Exposure to PM_2.5, a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fe...

**aoyu Wei, Zhonghao Zhang, Yayun Gu, Rong Zhang, Jie Huang, Feng Li… in Cell Discovery (2024)

Article

Improved therapeutic consistency and efficacy of CD317⁺ MSCs through stabilizing TSG6 by PTX3

Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expan...

Shaoquan Shi, Si Chen, Bowei Liang, Yumeng Li, Qi Ma… in Stem Cell Research & Therapy (2024)

Article

Transplantation of the LRP1^high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice

Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demons...

Jiacheng Shen, Li Wu, **aoying Shi, Gang Chen, Tingwei Liu… in Stem Cell Research & Therapy (2024)

Article

HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis

HOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3 in the pathogenesis of gastric cancer (GC) remains incomplet...

Kexi Yang, Juntao Li, **ghan Zhu, Yuqi Chen, Yuxin He, Jiayu Wang… in Cell Death Discovery (2024)

Article

HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification

Aerobic glycolysis has been shown to play a key role in tumor cell proliferation and metastasis. However, how it is directly regulated is largely unknown. Here, we found that HES1 expression was significantly ...

Jiayu Wang, Mengxin Zhu, **ghan Zhu, Juntao Li, **ngchao Zhu… in Cell Death Discovery (2023)

Article

Circular RNA circLDLR facilitates cancer progression by altering the miR-30a-3p/SOAT1 axis in colorectal cancer

Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been reported to play critical regulatory roles in tumorigenesis, serving as tumor biomarkers and therapeuti...

Ruoqin Wang, Jiayu Wang, Yanjun Chen, Yuqi Chen, Qinhua **… in Cell Death Discovery (2022)

Article

Risk factors for recurrent positive results of the nucleic acid amplification test for COVID-19 patients: a retrospective study

Positive retests of COVID-19 represent a public health concern because of the increased risk of transmission. This study explored whether factors other than the nucleic acid amplification test (NAAT) contribut...

Wanwan Yi, Xuan Long, ** Liu, LiShuai Shi, Zichen Chen, **g Yang, Ziyu Yang… in Human Cell (2021)

Article

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly contagious and causes lymphocytopenia, but the underlying mechanisms are poorly understood. We demonstrate here that heterotypic...

Zhengrong Zhang, You Zheng, Zubiao Niu, Bo Zhang… in Cell Death & Differentiation (2021)

Article

Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1α/CXCR4

Neointimal hyperplasia remains a major obstacle in vascular regeneration. Sca-1-positive progenitor cells residing within the vascular adventitia play a crucial role in the assemblage of vascular smooth muscle...

Yan Wu, Yuan-** Li, Liu-liu Shi, Yun Liu, Yan Wang… in Stem Cell Research & Therapy (2021)

Article

Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development

Lin Zhao, Songguo Xue, Zhongyuan Yao, Juanzi Shi, Biaobang Chen, Ling Wu… in Protein & Cell (2020)

Article

Correction to: Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

Since publication of this article, the authors reported that the names of the corresponding authors had been placed in the wrong order.

Min Wang, Chao Mao, Lianlian Ouyang, Yating Liu, Weiwei Lai… in Cell Death & Differentiation (2020)

Article

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a dynamic role in transcriptional and translational regulation, and is involved in cancer. However, the regulatory circuitry between ...

Min Wang, Chao Mao, Lianlian Ouyang, Yating Liu, Weiwei Lai… in Cell Death & Differentiation (2019)

Article

S100B is required for maintaining an intermediate state with double-positive Sca-1+ progenitor and vascular smooth muscle cells during neointimal formation

Accumulation of vascular smooth muscle cells (VSMCs) within the neointimal region is a hallmark of atherosclerosis and vessel injury. Evidence has shown that Sca-1-positive (Sca-1+) progenitor cells residing i...

Yan Wu, **n Liu, Ling-Yun Guo, Lei Zhang, Fei Zheng… in Stem Cell Research & Therapy (2019)

Article

Mesenchymal stem cells for the treatment of ulcerative colitis: a systematic review and meta-analysis of experimental and clinical studies

To explore the promising use of mesenchymal stem cells (MSCs) for ulcerative colitis (UC).

**ao Shi, Qi Chen, Fen Wang in Stem Cell Research & Therapy (2019)