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Article
Open AccessDevelopment and validation of a nomogram to predict overall survival for patients with metastatic renal cell carcinoma
Heterogeneity of metastatic renal cell carcinoma (RCC) constraints accurate prognosis prediction of the tumor. We therefore aimed at develo** a novel nomogram for accurate prediction of overall survival (OS)...
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Article
Open AccessYinang formulation versus placebo granules as a treatment for chronic kidney disease stages III–IV in patients with autosomal dominant polycystic kidney disease: study protocol for a double-blind placebo-controlled randomized clinical trial
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common potentially life-threatening inherited kidney diseases. It is the fourth most common cause of end-stage renal disease requiring re...
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Article
Open AccessCatheterization in a patient with end-stage renal disease through persistent left superior vena cava: a rare case report and literature review
Persistent left superior vena cava (PLSVC) is a common vena cava malformation, and drains blood into the right atrium via the dilated coronary sinus in most cases. It is usually asymptomatic and detected incid...
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Article
Open AccessCryo-EM structure of the polycystic kidney disease-like channel PKD2L1
PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in the sour sensation and other pH-dependent processes. PKD2L1 is believed to be a nonselective cation channel that can ...
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Article
The mutation-free embryo for in vitro fertilization selected by MALBAC-PGD resulted in a healthy live birth from a family carrying PKD 1 mutation
Autosomal dominant polycystic kidney disease (ADPKD, autosomal dominant PKD or adult-onset PKD) is the most prevalent and potentially lethal kidney disease that is hereditary and lacks effective treatment. Pre...
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Article
Sclerostin as a new key factor in vascular calcification in chronic kidney disease stages 3 and 4
Sclerostin is an osteocyte-derived inhibitor of the Wnt pathway and has been shown to play a key role in chronic kidney disease-mineral and bone disorder (CKD-MBD). The present study aimed to validate its pote...
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Article
Open AccessCarcinosarcoma of native renal pelvis in recipient after a renal transplant: a case report
Carcinosarcoma is a malignancy that rarely occurs in the renal pelvis.
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Article
Idiopathic nodular glomerulosclerosis in Chinese patients: a clinicopathologic study of 20 cases
The objective of this study is to investigate the frequency and clinicopathological features of idiopathic nodular glomerulosclerosis (ING) in Chinese patients, on which there has been no previously published ...
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Article
Open AccessThe therapeutic efficacy of I131-PSCA-mAb in orthotopic mouse models of prostate cancer
Prostate stem cell antigen (PSCA) is upregulated in prostate cancer tissues. Here we aimed to study the therapeutic efficacy of a monoclonal antibody of PSCA-labeled I131 (I131-PSCA-mAb) in orthotopic mouse model...
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Article
Androgen receptor in human prostate cancer-associated fibroblasts promotes prostate cancer epithelial cell growth and invasion
The androgens and androgen receptor (AR) play key roles in the prostate cancer (PCa) development and progression via epithelium-stroma cross talk. Prostate cancer-associated fibroblasts (CAFs) are dominant com...
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Differentiation of Dendritic Cells in Cultures of Rat and Mouse Bone Marrow Cells
Although dendritic cells originate from bone marrow, 1,2,3,4 they are not detectable in fresh preparations of bone marrow cells.5 We previously developed an in vitro system in which dendritic cells are produced w...
