65 Result(s)

Article

Plasma exosomes from patients with active thyroid-associated orbitopathy induce inflammation and fibrosis in orbital fibroblasts

The pathogenesis of thyroid-associated orbitopathy (TAO) remains incompletely understand. The interaction between immunocytes and orbital fibroblasts (OFs) play a critical role in orbital inflammatory and fibr...

Li Wei, Qinying Huang, Yunhai Tu, Shihan Song… in Journal of Translational Medicine (2024)

Article

The efficacy and safety of dalpiciclib, a cyclin-dependent kinase 4/6 inhibitor, in patients with advanced head and neck mucosal melanoma harboring CDK4 amplification

Mucosal melanoma (MM) is a rare but devastating subtype of melanoma. Our previous studies have demonstrated robust anti-tumor effects of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors in head and neck MM (HN...

Chaoji Shi, Houyu Ju, Rong Zhou, Shengming Xu, Yunteng Wu, Ziyue Gu… in BMC Medicine (2024)

Article

Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl₃ model

Exposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed...

Xueying **, Xueling Yue, Zhe Huang, **angkun Meng… in Cellular and Molecular Life Sciences (2024)

Article

Similar efficacy of ibrutinib arms across ALPINE and ELEVATE-RR trials in relapsed/refractory chronic lymphocytic leukemia: a matching-adjusted indirect comparison

Mazyar Shadman, Alessandra Tedeschi, Leyla Mohseninejad, Keri Yang… in Blood Cancer Journal (2024)

Article

Construction and validation of a hypoxia-related gene signature to predict the prognosis of breast cancer

Among the most common forms of cancer worldwide, breast cancer posed a serious threat to women. Recent research revealed a lack of oxygen, known as hypoxia, was crucial in forming breast cancer. This research ...

Chaoran Qiu, Wenjun Wang, Shengshan Xu, Yong Li, **gtao Zhu, Yiwen Zhang… in BMC Cancer (2024)

Article

Transurethral surgical treatment for benign prostatic hyperplasia with detrusor underactivity: a systematic review and meta-analysis

The efficacy of surgical treatment for benign prostatic hyperplasia (BPH) patients with detrusor underactivity (DU) remains controversial.

Peilin Zou, Chang Liu, Yucong Zhang, Chao Wei, **aming Liu… in Systematic Reviews (2024)

Article

Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy

Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates ep...

Dian Hu, Zerui Zhang, **angyuan Luo, Siwen Li, Junqing Jiang… in Biomarker Research (2024)

Article

Dry suction versus wet suction technique of endoscopic ultrasound-guided fine-needle biopsy for diagnosis of solid pancreatic lesions: study protocol of a multicenter randomized controlled non-inferiority trial

Studies have shown that the wet suction technique in endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) generates better histological diagnostic accuracy and specimen quality than the dry suction te...

Shenglin Xu, Junfen Wang, Jianian Guo, Fang **e, Weiguang Qiao, Yiteng Meng… in Trials (2023)

Article

Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling

Hepatic ischemia–reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT). Insulin-induced gene 2 (Insig2) is one of several proteins that anchor the...

Yichao Wu, Changbiao Li, Abid Ali Khan, Kangchen Chen… in Journal of Translational Medicine (2023)

Article

In-ear integrated sensor array for the continuous monitoring of brain activity and of lactate in sweat

Owing to the proximity of the ear canal to the central nervous system, in-ear electrophysiological systems can be used to unobtrusively monitor brain states. Here, by taking advantage of the ear’s exocrine swe...

Yuchen Xu, Ernesto De la Paz, Akshay Paul, Kuldeep Mahato… in Nature Biomedical Engineering (2023)

Article

Stretchable ultrasonic arrays for the three-dimensional map** of the modulus of deep tissue

Serial assessment of the biomechanical properties of tissues can be used to aid the early detection and management of pathophysiological conditions, to track the evolution of lesions and to evaluate the progre...

Hongjie Hu, Yuxiang Ma, **aoxiang Gao, Dawei Song… in Nature Biomedical Engineering (2023)

Article

Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice

Exposure to chronic psychological stress (CPS) is an intractable risk factor for inflammatory and metabolic diseases. Lysosomal cysteinyl cathepsins play an important role in human pathobiology. Given that cat...

Ying Wan, Limei Piao, Shengnan Xu, **angkun Meng… in Cellular and Molecular Life Sciences (2023)

Article

An eHealth symptom and complication management program for cancer patients with newly created ostomies and their caregivers (Alliance): a pilot feasibility randomized trial

Cancer patients with newly created ostomies face complications that reduce quality of life (QOL) and increase morbidity and mortality. This proof-of-concept study examined the feasibility, usability, acceptabi...

Shenmeng Xu, **anming Tan, Chunxuan Ma, Rebecca S. McElyea, Karl Shieh… in BMC Cancer (2023)

Article

Correction: Cytoplasmic poly(A)-binding protein 1 (PABPC1) is a prognostic biomarker to predict survival in nasopharyngeal carcinoma regardless of chemoradiotherapy

Feng Ling, Shengen Xu, **aochen Li, **ngwang Sun, Wenbo Long in BMC Cancer (2023)

Article

Cytoplasmic poly(A)-binding protein 1 (PABPC1) is a prognostic biomarker to predict survival in nasopharyngeal carcinoma regardless of chemoradiotherapy

Nasopharyngeal carcinoma (NPC), especially the nonkeratinizing type, is a malignant tumor primarily occurring in southern China and Southeast Asia. Chemotherapy (CT) and combined radiotherapy (RT) is used to t...

Feng Ling, Shengen Xu, **aochen Li, **ngwang Sun, Wenbo Long in BMC Cancer (2023)

Article

Effects of Malate Ringer's solution on myocardial injury in sepsis and enforcement effects of TPP@PAMAM-MR

Myocardial dysfunction played a vital role in organ damage after sepsis. Fluid resuscitation was the essential treatment in which Lactate Ringer's solution (LR) was commonly used. Since LR easily led to hyperl...

Lei Tan, Han She, Jie Zheng, **aoyong Peng, Ningke Guo… in Journal of Translational Medicine (2022)

Article

Hippocampal representations of foraging trajectories depend upon spatial context

Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and...

Wan-Chen Jiang, Sheng** Xu, Joshua T. Dudman in Nature Neuroscience (2022)