139 Result(s)

Article

Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model

Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake and milk production, which can lead to higher mortality rates in newborn piglets. The probiotic Lactobacillus...

Tianle Gao, Ran Li, Liang Hu, Quanfang Hu… in Journal of Animal Science and Biotechnology (2024)

Article

Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders

Neurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating childhood psychiatric conditions. Genetic factors are recognized as playing ...

Shengyun Xu, Jiaoxiang Wang, Kexin Mao, Deling Jiao, Zhu Li, Heng Zhao… in Cell & Bioscience (2024)

Article

Improvement of insulin sensitivity by dietary fiber consumption during late pregnant sows is associated with gut microbiota regulation of tryptophan metabolism

Dietary fiber (DF) consumption was reported to improve insulin sensitivity, change the tryptophan metabolism, and alter the gut microbiota. Herein, this study aimed to investigate the effects of DF consumption...

Yang Li, Jiaqi He, Lijia Zhang, Haoyu Liu, Meng Cao, Yan Lin… in Animal Microbiome (2024)

Article

Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl₃ model

Exposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed...

Xueying **, Xueling Yue, Zhe Huang, **angkun Meng… in Cellular and Molecular Life Sciences (2024)

Article

SSBlazer: a genome-wide nucleotide-resolution model for predicting single-strand break sites

Single-strand breaks are the major DNA damage in the genome and serve a crucial role in various biological processes. To reveal the significance of single-strand breaks, multiple sequencing-based single-strand...

Sheng Xu, Junkang Wei, Siqi Sun, Jizhou Zhang, Ting-Fung Chan, Yu Li in Genome Biology (2024)

Article

SOX on tumors, a comfort or a constraint?

The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role...

Junqing Jiang, Yufei Wang, Mengyu Sun, **angyuan Luo, Zerui Zhang… in Cell Death Discovery (2024)

Article

Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model

Intrauterine growth retardation (IUGR) affects intestinal growth, morphology, and function, which leads to poor growth performance and high mortality. The present study explored whether maternal dietary methyl...

Yan Lin, Jiangnan Wu, Yong Zhuo, Bin Feng… in Journal of Animal Science and Biotechnology (2024)

Article

Amino acid metabolism in tumor biology and therapy

Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling...

Jie Chen, Likun Cui, Shaoteng Lu, Sheng Xu in Cell Death & Disease (2024)

Article

Inhibition of demethylase by IOX1 modulates chromatin accessibility to enhance NSCLC radiation sensitivity through attenuated PIF1

Chromatin accessibility is a critical determinant of gene transcriptional expression and regulated by histones modification. However, the potential for manipulating chromatin accessibility to regulate radiatio...

Qian Li, Kexin Qin, Yushan Tian, Biao Chen, Guo** Zhao… in Cell Death & Disease (2023)

Article

Gp78 deficiency in hepatocytes alleviates hepatic ischemia-reperfusion injury via suppressing ACSL4-mediated ferroptosis

Ferroptosis, which is driven by iron-dependent lipid peroxidation, plays an essential role in liver ischemia-reperfusion injury (IRI) during liver transplantation (LT). Gp78, an E3 ligase, has been implicated ...

Changbiao Li, Yichao Wu, Kangchen Chen, Ronggao Chen, Shengjun Xu… in Cell Death & Disease (2023)

Article

CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in G_αs-G_αi coupling to the β₂-adrenergic receptor

In essence, the β₂ adrenergic receptor (β₂AR) plays an antiproliferative role by increasing the intracellular cyclic 3’,5’-adenosine monophosphate (cAMP) concentration through G_αs coupling, but interestingly, β₂A...

Mingli Ge, Li Wu, Feng He, Yu Tai, Ruhong Fang… in Cell Communication and Signaling (2023)

Article

Preweaning period is a critical window for rumen microbial regulation of average daily gain in Holstein heifer calves

Rumen bacterial groups can affect growth performance, such as average daily gain (ADG), feed intake, and efficiency. The study aimed to investigate the inter-relationship of rumen bacterial composition, rumen ...

Shengyang Xu, Chong Jiao, Qiyu Diao, Yan Tu in Journal of Animal Science and Biotechnology (2023)

Article

Correction: Optimization of a 2A self-cleaving peptide-based multigene expression system for efficient expression of upstream and downstream genes in silkworm

Yuancheng Wang, Feng Wang, Sheng Xu, Riyuan Wang… in Molecular Genetics and Genomics (2023)

Article

Correction: Optimization of a 2A self-cleaving peptide-based multigene expression system for efficient expression of upstream and downstream genes in silkworm

Yuancheng Wang, Feng Wang, Sheng Xu, Riyuan Wang… in Molecular Genetics and Genomics (2023)