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Article
Understanding Oral PrEP Interest, Uptake, Persistence, and Experience of Use Among Heterosexual Men in Johannesburg, South Africa: An Exploratory Pilot Study
South Africa’s PrEP programming has primarily focused on men who have sex with men and other key populations through dedicated clinical and outreach services. However, data shows that the pool of men vulnerabl...
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Article
A review of stereotactic ablative radiotherapy for nonmetastatic renal cell carcinoma
Renal cell carcinoma (RCC) is an uncommon malignancy whose incidence has been increasing over the past few decades, posing treatment challenges for elderly or infirm patients who are not surgical candidates. S...
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Article
Association of PSA kinetics after testosterone recovery with subsequent recurrence: secondary analysis of a phase III randomized controlled trial
After cessation of androgen deprivation therapy (ADT), testosterone gradually recovers to supracastrate levels (> 50 ng/dL). After this, rises in prostate-specific antigen (PSA) are often seen. However, it rem...
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Article
Impact of sequencing of androgen receptor-signaling inhibition and radiotherapy in prostate cancer: importance of homologous recombination disruption
The synergy of combining androgen receptor-signaling inhibition (ARSI) to radiotherapy (RT) in prostate cancer has been largely attributed to non-homologous end joining (NHEJ) inhibition. However, this mechani...
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Article
Development and validation of a multivariable prognostic model in de novo metastatic castrate sensitive prostate cancer
Metastatic castrate sensitive prostate cancer (mCSPC) is a heterogeneous disease state with variable prognosis. Although several life-prolonging systemic agents are available, there is no robust multivariable ...
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Article
Real-world utilization and outcomes of docetaxel among older men with metastatic prostate cancer: a retrospective population-based cohort study in Canada
The adoption of docetaxel for systemic treatment of metastatic prostate cancer (PCa), in both castration-sensitive (mCSPC) and castration-resistant (mCRPC) settings, is poorly understood. This study examined t...
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Article
Association of dynamic change in patient-reported pain with survival in metastatic castrate sensitive prostate cancer—exploratory analysis of LATITUDE study
Pain is an important dimension of quality-of-life in patients with metastatic castrate-sensitive prostate cancer (mCSPC). However, it is unclear if dynamic change in pain over time can predict for overall surv...
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Article
Long-term outcomes of prostate radiotherapy for newly-diagnosed metastatic prostate cancer
In patients presenting with metastatic prostate cancer, the role of local therapy is evolving. Two recently reported large-scale randomized trials suggest that radiotherapy (RT) directed at the prostate improv...
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Chapter
Target Delineation for Radiosurgery (Including Postoperative Cavity Radiosurgery) in Brain Metastases
Studies support the use of focal irradiation in a variety of clinical scenarios for patients with brain metastases (BMs), including single, multiple, and postresection. As such, more practitioners are performi...
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Article
Open AccessThe plasma peptides of breast versus ovarian cancer
There is a need to demonstrate a proof of principle that proteomics has the capacity to analyze plasma from breast cancer versus other diseases and controls in a multisite clinical trial design. The peptides o...
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Article
Open AccessThe plasma peptides of ovarian cancer
It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma by using liquid chromatography and tandem mass spectrometry to identify, quantify and compare the peptides cl...
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Article
Open AccessThe plasma peptidome
It may be possible to discover new diagnostic or therapeutic peptides or proteins from blood plasma using LC–ESI–MS/MS to identify, quantify and compare the statistical distributions of peptides cleaved ex viv...
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Article
Open AccessProposal of a post-prostatectomy clinical target volume based on pre-operative MRI: volumetric and dosimetric comparison to the RTOG guidelines
Recurrence rates following radiotherapy for prostate cancer in the post-operative adjuvant or salvage setting remain substantial. Previous work from our institution demonstrated that published prostate bed CTV...
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Article
Primary skull-based yolk-sac tumour: case report and review of central nervous system germ cell tumours
Primary intra-cranial germ-cell tumours (GCT) are rare and it is important to differentiate them histologically as their prognosis and treatment is quite different. Moreover, highly malignant non-germinomatous...
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Article
Small Angle Neutron Scattering Studies of Single Phase IPNs
Interpenetrating polymer networks (IPNs) have been synthesized from polymers that form miscible polymer blends. Full, semi-I and semi-II IPNs made from polystyrene-d8 and poly(vinylmethylether) can be made to ...
