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  1. Article

    Open Access

    Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export

    Parkinson’s disease (PD) is a progressive neurodegenerative brain disease presenting with a variety of motor and non-motor symptoms, loss of midbrain dopaminergic neurons in the substantia nigra pars compacta ...

    Shaun Martin, Stefanie Smolders, Chris Van den Haute, Bavo Heeman… in Acta Neuropathologica (2020)

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    Article

    ATP13A2 deficiency disrupts lysosomal polyamine export

    ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome—a parkinsonism with dementia1—and early-onset Parkin...

    Sarah van Veen, Shaun Martin, Chris Van den Haute, Veronick Benoy, Joseph Lyons… in Nature (2020)

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    Chapter

    Using the Open Standards-Based Framework for Planning and Implementing Ecosystem-Based Adaptation Projects in the High Mountainous Regions of Central Asia

    The ecosystems of the high mountain regions of Central Asia are rich in biodiversity and provide essential services, such as the regulation and provision of water for the population of the entire region. Howev...

    Paul Schumacher, Tobias Garstecki… in Theory and Practice of Climate Adaptation (2018)

  4. No Access

    Article

    EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

    We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments. To achieve this, we describe EV-TRACK, a crowdsourcin...

    Jan Van Deun, Pieter Mestdagh, Patrizia Agostinis, Özden Akay… in Nature Methods (2017)

  5. Article

    Open Access

    A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

    Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle isolation remains underexploited. We ...

    Arun Kumar Tharkeshwar, Jesse Trekker, Wendy Vermeire, Jarne Pauwels… in Scientific Reports (2017)

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