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  1. No Access

    Article

    In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201)

    In 2014, NM-2201 (CBL-2201), a novel synthetic cannabinoid (SC), was detected by scientists at Russian and US laboratories. It has been already added to the list of scheduled drugs in Japan, Sweden and Germany...

    **ngxing Diao, Jeremy Carlier, Mingshe Zhu, Shaokun Pang… in Forensic Toxicology (2017)

  2. No Access

    Article

    Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry

    Carfentanil is an ultra-potent synthetic opioid. No human carfentanil metabolism data are available. Reportedly, Russian police forces used carfentanil and remifentanil to resolve a hostage situation in Moscow...

    Michael G. Feasel, Ariane Wohlfarth, John M. Nilles, Shaokun Pang… in The AAPS Journal (2016)

  3. Article

    Open Access

    Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes

    Since 2013, a new drugs-of-abuse trend attempts to bypass drug legislation by marketing isomers of scheduled synthetic cannabinoids (SCs), e.g., FUBIMINA (BIM-2201) and THJ-2201. It is much more challenging to...

    **ngxing Diao, Karl B. Scheidweiler, Ariane Wohlfarth, Mingshe Zhu… in Forensic Toxicology (2016)

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  4. Article

    In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22

    In 2014, FDU-PB-22 and FUB-PB-22, two novel synthetic cannabinoids, were detected in herbal blends in Japan, Russia, and Germany and were quickly added to their scheduled drugs list. Unfortunately, no human me...

    **ngxing Diao, Karl B. Scheidweiler, Ariane Wohlfarth, Shaokun Pang… in The AAPS Journal (2016)

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  5. No Access

    Article

    Identification of AB-FUBINACA metabolites in human hepatocytes and urine using high-resolution mass spectrometry

    AB-FUBINACA, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide, is an indazole synthetic cannabinoid identified in drug seizures around the world. Few metabolism data are available...

    Marisol S. Castaneto, Ariane Wohlfarth, Shaokun Pang, Mingshe Zhu… in Forensic Toxicology (2015)

  6. No Access

    Article

    Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA

    Whereas non-fluoropentylindole/indazole synthetic cannabinoids appear to be metabolized preferably at the pentyl chain though without clear preference for one specific position, their 5-fluoro analogs’ major m...

    Ariane Wohlfarth, Marisol S. Castaneto, Mingshe Zhu, Shaokun Pang… in The AAPS Journal (2015)

  7. No Access

    Article

    Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry

    PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are new synthetic cannabinoids with a quinoline substructure and...

    Ariane Wohlfarth, Adarsh S. Gandhi, Shaokun Pang… in Analytical and Bioanalytical Chemistry (2014)

  8. No Access

    Article

    First Characterization of AKB-48 Metabolism, a Novel Synthetic Cannabinoid, Using Human Hepatocytes and High-Resolution Mass Spectrometry

    Since the federal authorities scheduled the first synthetic cannabinoids, JWH-018 and JWH-073, new synthetic cannabinoids were robustly marketed. N-(1-Adamantyl)-1-pentylindazole-3-carboxamide (AKB-48), also know...

    Adarsh S. Gandhi, Mingshe Zhu, Shaokun Pang, Ariane Wohlfarth… in The AAPS Journal (2013)