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  1. No Access

    Article

    Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain

    Chronic neuropathic pain is a debilitating condition that remains challenging to treat. Glutamate N-methyl-d-aspartate receptor (NMDAR) antagonists have been used to treat neuropathic pain, but the exact sites of...

    Meichun Deng, Shao-Rui Chen, Hui-Lin Pan in Cellular and Molecular Life Sciences (2019)

  2. Article

    C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling

    Phosphodiesterase-9A (PDE9A) expression is upregulated during cardiac hypertrophy and heart failure. Accumulating evidence suggests that PDE9A might be a promising therapeutic target for heart diseases. The pr...

    Pan-xia Wang, Zhuo-ming Li, Si-dong Cai, **g-yan Li, ** He… in Acta Pharmacologica Sinica (2017)

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  3. Article

    Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling

    We previously identified AG-690/11026014 (6014) as a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor that effectively prevented angiotensin II (Ang II)-induced cardiomyocyte hypertrophy. In the present ...

    Guo-shuai Feng, Cui-ge Zhu, Zhuo-ming Li, Pan-xia Wang… in Acta Pharmacologica Sinica (2017)

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  4. No Access

    Article

    Aristoyunnolin H attenuates extracellular matrix secretion in cardiac fibroblasts by inhibiting calcium influx

    Aristoyunnolin H is a novel aristophyllene sesquiterpenoid isolated from the traditional Chinese medicine Aristolochia yunnanensis Franch. The present research was designed to explore the anti-fibrotic effects of...

    Shao-rui Chen, Wen-** Zhang, **g-mei Bao… in Archives of Pharmacal Research (2017)

  5. No Access

    Chapter

    NMDA Receptors and Signaling in Chronic Neuropathic Pain

    Chronic pain, especially neuropathic pain resulting from damage to the peripheral or central nervous system, is a major clinical problem that remains difficult to treat. The glutamate N-methyl-d-aspartate recepto...

    Geoffroy Laumet, Shao-Rui Chen, Hui-Lin Pan in The NMDA Receptors (2017)

  6. No Access

    Article

    G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition

    Chronic neuropathic pain is associated with K+ channel downregulation in primary sensory neurons. The authors show that G9a, a histone-modifying enzyme, is required for transcriptional repression of K+ channel–as...

    Geoffroy Laumet, Judit Garriga, Shao-Rui Chen, Yuhao Zhang… in Nature Neuroscience (2015)

  7. No Access

    Article

    Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease

    The authors show that a nonpsychoactive cannabinoid, DH-CBD, can rescue exaggerated acoustic startle phenotypes caused by startle disease–causing point mutations in the glycine receptor (GlyR) α1 subunit. Homo...

    Wei **ong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao… in Nature Neuroscience (2014)

  8. No Access

    Article

    Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways

    Cryptotanshinone (CTS), a major constituent extracted from the medicinal herb Salvia miltiorrhiza Bunge, has well-documented antioxidative and anti-inflammatory effects. In the present study, the pharmacological ...

    Shu Tang, **ao-Yan Shen, He-Qing Huang, Suo-Wen Xu, Yang Yu, Chang-Hua Zhou… in Inflammation (2011)

  9. No Access

    Article

    Reduced expression of GSTM2 and increased oxidative stress in spontaneously hypertensive rat

    Human essential hypertension is a complex polygenic trait with underlying genetic components that remain unknown. The spontaneously hypertensive rat (SHR) is a well-characterized experimental model for essenti...

    Si-Gui Zhou, ** Wang, Rong-Biao Pi, Jie Gao… in Molecular and Cellular Biochemistry (2008)