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  1. Article

    Open Access

    FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2α blockade by facilitating LDHA phosphorylation

    Renal cell carcinoma (RCC) is one of the three major malignant tumors of the urinary system and originates from proximal tubular epithelial cells. Clear cell renal cell carcinoma (ccRCC) accounts for approxima...

    Ren Liu, Zhihao Zou, Lingwu Chen, Yuanfa Feng, Jianheng Ye in Cell Death & Disease (2024)

  2. Article

    Open Access

    Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer

    The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregu...

    Jianheng Ye, Shanghua Cai, Yuanfa Feng in Signal Transduction and Targeted Therapy (2023)