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within Shahir S. Rizk Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody

    We have utilized a high-diversity phage display library to engineer antibody fragments (Fabs) that can modulate the activity of the enzyme isocitrate dehydrogenase 1 (IDH1). We show that a conformation-specifi...

    Shahir S. Rizk, Somnath Mukherjee, Akiko Koide, Shohei Koide… in Scientific Reports (2017)

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  2. No Access

    Article

    A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

    Artemisinins are key anti-malarial drugs, but artemisinin resistance has been increasing; this study identifies the molecular target of artemisinins as phosphatidylinositol-3-kinase and increase of the lipid p...

    Alassane Mbengue, Souvik Bhattacharjee, Trupti Pandharkar, Haining Liu… in Nature (2015)