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    Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins

    Allosteric effectors have the ability to modulate protein-ligand interactions in a controlled fashion. Now a novel class of antibody-like affinity reagents, synthetic antigen binders or sABs, are generated in vit...

    Shahir S Rizk, Marcin Paduch, John H Heithaus… in Nature Structural & Molecular Biology (2011)