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  1. No Access

    Article

    Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

    Aging is a major factor involved in neurological impairments, decreased anti-oxidant activities, and enhanced neuroinflammation. D-galactose (D-gal) has been considered an artificial aging model which induces ...

    Shafiq Ur Rehman, Shahid Ali Shah, Tahir Ali, Jong Il Chung… in Molecular Neurobiology (2017)

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    Article

    Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice

    Alzheimer’s disease (AD) is a devastating and progressive neurodegenerative disease and is characterized pathologically by the accumulation of amyloid beta (Aβ) and the hyperphosphorylation of tau proteins in ...

    Ashfaq Ahmad, Tahir Ali, Hyun Young Park, Haroon Badshah… in Molecular Neurobiology (2017)

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    Article

    Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an Aβ1–42 Mouse Model of Alzheimer’s Disease

    Nanomedicine is an emerging research area. In this study, we investigated the neuroprotective efficacy of anthocyanin-loaded polyethylene glycol-gold nanoparticles (PEG-AuNPs) for enhancing the neuroprotective...

    Tahir Ali, Min Ju Kim, Shafiq Ur Rehman, Ashfaq Ahmad… in Molecular Neurobiology (2017)

  4. No Access

    Article

    Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

    Well-established studies have shown an elevated level of reactive oxygen species (ROS) that induces oxidative stress in the Alzheimer’s disease (AD) patient’s brain and an animal model of AD. Herein, we invest...

    Tahir Ali, Taehyun Kim, Shafiq Ur Rehman, Muhammad Sohail Khan… in Molecular Neurobiology (2018)

  5. No Access

    Article

    Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus

    Microglia play a crucial role in the inflammatory brain response to infection. However, overactivation of microglia is neurotoxic. Toll-like receptor 4 (TLR4) is involved in microglial activation via lipopolys...

    Shafiq Ur Rehman, Tahir Ali, Sayed Ibrar Alam, Rahat Ullah… in Molecular Neurobiology (2019)

  6. No Access

    Article

    Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

    Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No comprehensive studies have shown its protective effects in neurodegenerative disorders. Here, we hypothesized that hesperetin may p...

    Muhammad Ikram, Tahir Muhammad, Shafiq Ur Rehman, Amjad Khan… in Molecular Neurobiology (2019)