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  1. Article

    Open Access

    Pharmacokinetics and Bioequivalence of Memantine Tablet and a New Dry Syrup Formulation in Healthy Japanese Males: Two Single-Dose Crossover Studies

    Memantine hydrochloride, an N-methyl-D-aspartate receptor antagonist, is used to treat Alzheimer’s disease (AD). A new dry syrup formulation containing memantine hydrochloride has been developed to improve med...

    Yutaro Maekawa, Setsuo Hasegawa, Tomoko Ishizuka, Kazuhito Shiosakai… in Advances in Therapy (2019)

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  2. Article

    Open Access

    Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans

    Hyperglycemia caused by excessive intake of sucrose leads to lifestyle-related diseases such as diabetes. Administration of a lactic acid bacterial strain to mice suppresses sucrose-induced hyperglycemia, but ...

    Yasuhiko Matsumoto, Masaki Ishii, Setsuo Hasegawa… in Communications Biology (2019)

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  3. No Access

    Article

    Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study

    Vonoprazan (TAK-438) is a novel potassium-competitive acid blocker that inhibits gastric H+, K+-ATPase. The objectives of this study were to evaluate the influence of triple therapy with vonoprazan–amoxicillin–cl...

    Yuuichi Sakurai, Madoka Shiino, Hiroyuki Okamoto, Akira Nishimura… in Advances in Therapy (2016)

  4. No Access

    Article

    Dose–response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes

    This study was designed to investigate the antisecretory activity of rabeprazole administered once daily in doses of 5, 10, 20, and 40 mg and different cytochrome P450 2C19 (CYP2C19) genotypes on gastric pH in...

    Seiichi Hayato, Setsuo Hasegawa… in European Journal of Clinical Pharmacology (2012)

  5. No Access

    Article

    Trastuzumab-induced CCL20 and interleukin-8 mRNA in human whole blood ex vivo

    Heparinized human whole blood from 16 adult volunteers was stimulated with achievable blood concentrations of trastuzumab and rituximab at 37°C for 4 h, then CCL20, IL8, and β-actin mRNA were quantified. The f...

    Setsuo Hasegawa, Hideaki Kato, Hiroki Yamaguchi… in Investigational New Drugs (2009)

  6. No Access

    Article

    Bioequivalence of Rebamipide Granules and Tablets in Healthy Adult Male Volunteers

    Objective: Rebamipide tablets, which are used in the treatment of patients with gastric ulcers or gastritis, can be difficult to administer in subjects with reduced swallowing ability or impaired...

    Setsuo Hasegawa, Hisakuni Sekino, Osamu Matsuoka… in Clinical Drug Investigation (2003)