18 Result(s)
within
Seth Blackshaw
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessIntercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how intercellular communication contributes to retinal ganglion cel...
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Article
Open AccessCommon and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina
Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG) reprogramming and asymmetric cell division that produces a multipotent Müller glia-der...
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Open AccessA clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus
Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila, the clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks and cy...
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Ptbp1 deletion does not induce astrocyte-to-neuron conversion
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Article
Open AccessCell-specific regulation of gene expression using splicing-dependent frameshifting
Precise and reliable cell-specific gene delivery remains technically challenging. Here we report a splicing-based approach for controlling gene expression whereby separate translational reading frames are coup...
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Open AccessIn vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration
Leber congenital amaurosis (LCA) is the most common cause of inherited retinal degeneration in children. LCA patients with RPE65 mutations show accelerated cone photoreceptor dysfunction and death, resulting in e...
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Open AccessAuthor Correction: The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
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Article
Open AccessAuthor Correction: A potential role for somatostatin signaling in regulating retinal neurogenesis
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Open AccessA potential role for somatostatin signaling in regulating retinal neurogenesis
Neuropeptides have been reported to regulate progenitor proliferation and neurogenesis in the central nervous system. However, these studies have typically been conducted using pharmacological agents in ex viv...
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Open AccessTemperature and species-dependent regulation of browning in retrobulbar fat
Retrobulbar fat deposits surround the posterior retina and optic nerve head, but their function and origin are obscure. We report that mouse retrobulbar fat is a neural crest-derived tissue histologically and ...
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Open AccessThe cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
The hypothalamus is a central regulator of many innate behaviors essential for survival, but the molecular mechanisms controlling hypothalamic patterning and cell fate specification are poorly understood. To i...
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Open AccessASCOT identifies key regulators of neuronal subtype-specific splicing
Public archives of next-generation sequencing data are growing exponentially, but the difficulty of marshaling this data has led to its underutilization by scientists. Here, we present ASCOT, a resource that u...
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Article
Open AccessTissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium
Accurate analysis of gene expression in human tissues using RNA sequencing is dependent on the quality of source material. One major source of variation in mRNA quality is post-mortem time. While it is known t...
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Article
Open AccessATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
Age-related macular degeneration (AMD) is a significant cause of vision loss in the elderly. The extent to which epigenetic changes regulate AMD progression is unclear. Here we globally profile chromatin acces...
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Correction: Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
Nature 548, 582–587 (2017); doi:10.1038/nature23663 In this Letter, the surname of author Vassilis Pachnis was misspelled as ‘Pachinis’. The original Letter has been corrected online.
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Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
GABAergic Lhx6+ neurons in the ventral zona incerta promote both rapid eye movement and non-rapid eye movement sleep and inhibit the activity of wake-promoting GABAergic and Hcrt+ neurons of the lateral hypothala...
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Open AccessThe long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states
Despite their abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poorly understood. Here we show that the long non-coding RNA, NEAT1, directly modulates neuronal exc...
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Open AccessMultiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis
Müller glia (MG) are the principal glial cell type in the vertebrate retina. Recent work has identified the LIM homeodomain factor encoding gene Lhx2 as necessary for both Notch signaling and MG differentiation i...
