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    Hydrophobic Mutagenesis and Semi-rational Engineering of Arginine Deiminase for Markedly Enhanced Stability and Catalytic Efficiency

    Due to its systemic arginine degradation, arginine deiminase (ADI) has attracted attentions as an anti-tumor drug. Its low activity at physiological conditions among other limitations has necessitated its engi...

    Serwanja Jamil, Meng-Han Liu, Yong-Mei Liu… in Applied Biochemistry and Biotechnology (2015)