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Open AccessAuthor Correction: Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
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A shock flash breaking out of a dusty red supergiant
Shock-breakout emission is light that arises when a shockwave, generated by the core-collapse explosion of a massive star, passes through its outer envelope. Hitherto, the earliest detection of such a signal w...
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Open AccessFully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in vitro has required the add...
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Open AccessSeeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43, amyotrophic lateral sclerosis and ...
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Open AccessStructural insights into the regulation of Cas7-11 by TPR-CHAT
The CRISPR-guided caspase (Craspase) complex is an assembly of the target-specific RNA nuclease known as Cas7-11 bound to CRISPR RNA (crRNA) and an ancillary protein known as TPR-CHAT (tetratricopeptide repeat...
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Properties of Spectra of Boundary Value Problems in Cylindrical and Quasicylindrical Domains
General formally self-adjoint boundary value problems with spec tral parameter are investigated in domains with cylindrical and quasicylin drical (periodic) outlets to infinity. The structure of the spectra is...
