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Article
Open AccessTargeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions. In addition to fusions, a considerable fraction of iCCA...
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Article
Open Access3D hotspots of recurrent retroviral insertions reveal long-range interactions with cancer genes
Genomically distal mutations can contribute to the deregulation of cancer genes by engaging in chromatin interactions. To study this, we overlay viral cancer-causing insertions obtained in a murine retroviral ...
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Article
Open AccessIntegration of gene expression and DNA-methylation profiles improves molecular subtype classification in acute myeloid leukemia
Acute Myeloid Leukemia (AML) is characterized by various cytogenetic and molecular abnormalities. Detection of these abnormalities is important in the risk-classification of patients but requires laborious exp...
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Article
Open AccessHighlights from the Third European International Society for Computational Biology (ISCB) Student Council Symposium 2014
In this meeting report, we give an overview of the talks, presentations and posters presented at the third European Symposium of the International Society for Computational Biology (ISCB) Student Council. The ...
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Article
Open AccessDetecting recurrent gene mutation in interaction network context using multi-scale graph diffusion
Delineating the molecular drivers of cancer, i.e. determining cancer genes and the pathways which they deregulate, is an important challenge in cancer research. In this study, we aim to identify pathways of fr...
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Chapter and Conference Paper
Integrating Protein Family Sequence Similarities with Gene Expression to Find Signature Gene Networks in Breast Cancer Metastasis
Finding robust marker genes is one of the key challenges in breast cancer research. Significant signatures identified in independent datasets often show little to no overlap, possibly due to small sample size,...
