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  1. Article

    Open Access

    CXCL10 is produced in hepatitis A virus-infected cells in an IRF3-dependent but IFN-independent manner

    Acute hepatitis A caused by hepatitis A virus (HAV) infection is accompanied by severe liver injury in adult patients, and the liver injury is associated with the production of chemokines. Herein, we investiga...

    Pil Soo Sung, Seon-Hui Hong, Jeewon Lee, Su-Hyung Park… in Scientific Reports (2017)

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  2. Article

    Open Access

    IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection

    Genetic polymorphisms in IFNL4 have been shown to predict responses to IFN-α-based therapy in hepatitis C virus (HCV)-infected patients. The IFNL4-ΔG genotype, which encodes functional IFN-λ4 protein, is associat...

    Pil Soo Sung, Seon-Hui Hong, Jae-Hee Chung, Sojeong Kim… in Scientific Reports (2017)

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  3. Article

    Open Access

    Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner

    By changing the relative abundance of generated antigenic peptides through alterations in the proteolytic activity, interferon (IFN)-γ-induced immunoproteasomes influence the outcome of CD8+ cytotoxic T lymphocyt...

    In Soo Oh, Kathrin Textoris-Taube, Pil Soo Sung… in Experimental & Molecular Medicine (2016)

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