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Article
Open AccessCXCL10 is produced in hepatitis A virus-infected cells in an IRF3-dependent but IFN-independent manner
Acute hepatitis A caused by hepatitis A virus (HAV) infection is accompanied by severe liver injury in adult patients, and the liver injury is associated with the production of chemokines. Herein, we investiga...
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Article
Open AccessIFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection
Genetic polymorphisms in IFNL4 have been shown to predict responses to IFN-α-based therapy in hepatitis C virus (HCV)-infected patients. The IFNL4-ΔG genotype, which encodes functional IFN-λ4 protein, is associat...
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Article
Complete prevention of blood loss with self-sealing haemostatic needles
Bleeding is largely unavoidable following syringe needle puncture of biological tissues and, while inconvenient, this typically causes little or no harm in healthy individuals. However, there are certain circu...
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Article
Open AccessImmunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner
By changing the relative abundance of generated antigenic peptides through alterations in the proteolytic activity, interferon (IFN)-γ-induced immunoproteasomes influence the outcome of CD8+ cytotoxic T lymphocyt...
