3 Result(s)

Article

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage

Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43, amyotrophic lateral sclerosis and ...

Senthil T. Kumar, Sergey Nazarov, Sílvia Porta, Niran Maharjan… in Nature Neuroscience (2023)

Article

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally modified forms accumulate in pa...

Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher… in npj Parkinson's Disease (2023)

Article

Author Correction: Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

Melek Firat Altay, Senthil T. Kumar, Johannes Burtscher… in npj Parkinson's Disease (2024)