58 Result(s)
within
Sen-**g Chen
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessObservation of heat pum** effect by radiative shuttling
Heat shuttling phenomenon is characterized by the presence of a non-zero heat flow between two bodies without net thermal bias on average. It was initially predicted in the context of nonlinear heat conduction...
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Open AccessComparative optimization of polysaccharide-based nanoformulations for cardiac RNAi therapy
Ionotropic gelation is widely used to fabricate targeting nanoparticles (NPs) with polysaccharides, leveraging their recognition by specific lectins. Despite the fabrication scheme simply involves self-assembl...
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Open AccessA complete reference genome of broomcorn millet
Broomcorn millet (Panicum miliaceum L.), known for its traits of drought resistance, adaptability to poor soil, short growth period, and high photosynthetic efficiency as a C4 plant, represents one of the earlies...
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Article
Open AccessSphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α
Non-alcoholic steatohepatitis (NASH) is a severe type of the non-alcoholic fatty liver disease (NAFLD). NASH is a growing global health concern due to its increasing morbidity, lack of well-defined biomarkers ...
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Open AccessEmx2 underlies the development and evolution of marsupial gliding membranes
Phenotypic variation among species is a product of evolutionary changes to developmental programs1,2. However, how these changes generate novel morphological traits remains largely unclear. Here we studied the ge...
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Graphene nanoribbons grown in hBN stacks for high-performance electronics
Van der Waals encapsulation of two-dimensional materials in hexagonal boron nitride (hBN) stacks is a promising way to create ultrahigh-performance electronic devices1–4. However, contemporary approaches for achi...
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Article
Open AccessSelective hydrodeoxygenation of α, β-unsaturated carbonyl compounds to alkenes
Achieving selective hydrodeoxygenation of α, β-unsaturated carbonyl groups to alkenes poses a substantial challenge due to the presence of multiple functional groups. In this study, we develop a ZnNC-X catalys...
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Open AccessCyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy
Overexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-XL can render tumor cells malignant. Leukemia drug venetoclax is currently the only approved selective BCL-2 inhibitor. However, ...
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Open AccessGenerating active metal/oxide reverse interfaces through coordinated migration of single atoms
Identification of active sites in catalytic materials is important and helps establish approaches to the precise design of catalysts for achieving high reactivity. Generally, active sites of conventional heter...
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Article
Open AccessDiscovery of lung adenocarcinoma tumor antigens and ferroptosis subtypes for develo** mRNA vaccines
mRNA vaccines are becoming a feasible alternative for treating cancer. To develop mRNA vaccines against LUAD, potential antigens were identified and LUAD ferroptosis subtypes distinguished for selecting approp...
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Open AccessUnraveling the genetic architecture of congenital vertebral malformation with reference to the develo** spine
Congenital vertebral malformation, affecting 0.13–0.50 per 1000 live births, has an immense locus heterogeneity and complex genetic architecture. In this study, we analyze exome/genome sequencing data from 873...
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Open AccessMutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response
Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor development and progression. The ...
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Article
Open AccessSoil organic carbon stocks increased across the tide-induced salinity transect in restored mangrove region
Blue carbon in mangrove ecosystems contributes significantly to the global carbon cycle. However, large uncertainties maintain in the soil organic carbon (SOC) storage throughout the tide-induced salinity and ...
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Article
Open AccessStress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion
Previous studies have speculated that brain activity directly controls immune responses in lymphoid organs. However, the upstream brain regions that control lymphoid organs and how they interface with lymphoid...
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Open AccessThe PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to overcome resistance1,2. The protein tyrosine phosphatases...
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Article
Nuclear export of pre-60S particles through the nuclear pore complex
The nuclear pore complex (NPC) is the bidirectional gate that mediates the exchange of macromolecules or their assemblies between nucleus and cytoplasm1–3. The assembly intermediates of the ribosomal subunits, pr...
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Open AccessIn situ observation of crystal rotation in Ni-based superalloy during additive manufacturing process
Understanding the dynamic process of epitaxial microstructure forming in laser additive manufacturing is very important for achieving products with a single crystalline texture. Here, we perform in situ, real-...
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Open AccessEpigenetic landscape reveals MECOM as an endothelial lineage regulator
A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine. Recent studies found that unique epigenetic signatures preferentially regulate cell id...
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Targeting TBK1 to overcome resistance to cancer immunotherapy
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking1,2. Here we identify the innate immune kinase TANK-bin...
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Open AccessA hydrophobic Cu/Cu2O sheet catalyst for selective electroreduction of CO to ethanol
Electrocatalytic reduction of carbon monoxide into fuels or chemicals with two or more carbons is very attractive due to their high energy density and economic value. Herein we demonstrate the synthesis of a h...
