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Open AccessAnatomical differences in nociceptor neurons sensitivity
Dorsal Root Ganglia (DRG) neurons are derived from the neural crest and mainly innervate the skin, while Jugular Nodose Complex (JNC) neurons originate from the placode and innervate internal organs. These gan...
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Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation1,2, but whether nociceptors also interact with...
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Article
Open AccessNeuronal Circuits Modulate Antigen Flow Through Lymph Nodes
When pathogens and toxins breech the epithelial barrier, antigens are transported by the lymphatic system to lymph nodes. In previously immunized animals, antigens become trapped in the draining lymph nodes, b...