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Article
Open AccessA common gene signature of the right ventricle in failing rat and human hearts
The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic changes occurring over months in isolated cardiomyocytes or who...
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Article
Open AccessSha** a suitable EU HTA dossier template: why the German template is not fit for purpose
From 2025, Health Technology Developers (HTDs) have to submit EU HTA dossiers. The joint clinical assessment (JCA) aims to streamline HTA processes and access to medicinal products across Europe. Currently, Ge...
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Article
Open AccessEvaluating ChatGPT-4V in chest CT diagnostics: a critical image interpretation assessment
To assess the diagnostic accuracy of ChatGPT-4V in interpreting a set of four chest CT slices for each case of COVID-19, non-small cell lung cancer (NSCLC), and control cases, thereby evaluating its potential ...
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Article
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
The right ventricle (RV) differs developmentally, anatomically and functionally from the left ventricle (LV). Therefore, characteristics of LV adaptation to chronic pressure overload cannot easily be extrapola...
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Chapter and Conference Paper
Data Friction: Physics-Inspired Metaphor to Evaluate the Technical Difficulties in Trustworthy Data Sharing
Data sharing between organizations is becoming an ever-increasing necessity. Data sharing allows organizations to improve business processes that depend on what happens in other organizations, just as having d...
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Article
Open AccessMethod for potential assessment and adaptation for additive manufacturing of conventionally manufactured components
The novelty of additive manufacturing (AM) involves new requirements, restrictions and rules, that are considerably different to those of conventional manufacturing methods. Therefore, designers often lack exp...
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Article
Open AccessA transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress
The family of hypoxia-inducible transcription factors (HIF) is activated to adapt cells to low oxygen conditions, but is also known to regulate some biological processes under normoxic conditions. Here we show...
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Chapter and Conference Paper
Towards Serverless Data Exchange Within Federations
In this paper, we propose a novel approach for sharing privacy-sensitive data across federations of independent organizations, taking particular regard to flexibility and efficiency. Our approach benefits from...
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Chapter and Conference Paper
Restructuring of Product Architecture Towards Additive Manufacturing Through Functional Analysis for High Temperature Applications
Evaluation tables, which are often used for identification of potentially profitable additively manufactured (AM) parts, are widely based on AM-expert knowledge. In many applications these approaches suffer fr...
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Article
Open AccessTowards compatibility of EUnetHTA JCA methodology and German HTA: a systematic comparison and recommendations from an industry perspective
The transferability of the EU joint clinical assessment (JCA) reports for pharmaceuticals for the German benefit assessment was evaluated by systematically comparing EU JCA and German clinical assessments (CA)...
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Chapter and Conference Paper
Synthesizing Configuration Tactics for Exercising Hidden Options in Serverless Systems
A proper configuration of an information system can ensure accuracy and efficiency, among other system objectives. Conversely, a poor configuration can have a significant negative impact on the system’s perfor...
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Chapter and Conference Paper
Application-Platform Co-design for Serverless Data Processing
“Application-platform co-design” refers to the phenomenon of new platforms being created in response to changing application needs, followed by application design and development changing due to the emergence ...
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Chapter and Conference Paper
Diminuendo! Tactics in Support of FaaS Migrations
Function-as-a-Service (FaaS) receives close attention due to highly desirable characteristics, including pay-as-you-go pricing, high elasticity, and its fully managed nature. To leverage these benefits for exi...
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Chapter
Intra-Datacenter Network Architectures
This Handbook chapter provides an overview of existing interconnection topologies and architectures for large-scale cloud computing systems. We discuss (a) tree-based solutions (also referred to as indirect to...
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Article
Dual-energy CT for liver iron quantification in patients with haematological disorders
To retrospectively quantify liver iron content in haematological patients suspected of transfusional haemosiderosis using dual-energy CT (DECT) and correlate with serum ferritin levels and estimated quantity o...
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Article
Functional magnetic resonance urography in infants: feasibility of a feed-and-sleep technique
Functional magnetic resonance (MR) urography has been well established in the diagnostic workup of congenital anomalies of kidneys and urinary tract, though long acquisition time requires sedation or general a...
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Article
Insights into fungal communities colonizing the acarosphere in a forest soil habitat
Knowledge on the diversity and ecology of microfungi associated with soil-dwelling mites is rather limited. To get insights into associations between the two highly diverse groups, we studied composition and p...
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Chapter and Conference Paper
Modelling the World of a Smart Room for Robotic Co-working
Robots come out of the cage. Soon, it will be possible to interact with free-standing robots along an assembly line or in a manufacturing workshop (robotic co-working). New sensitive robot arms have appeared on t...
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Chapter and Conference Paper
Designing Suitable Access Control for Web-Connected Smart Home Platforms
Access control in web-connected smart home platforms exhibits unique characteristics and challenges. In this paper, we therefore discuss suitable access control mechanisms specifically tailored to such platfor...
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Article
Comprehensive analysis of the in vitro and ex ovo hemocompatibility of surface engineered iron oxide nanoparticles for biomedical applications
A set of biomedically relevant iron oxide nanoparticles with systematically modified polymer surfaces was investigated regarding their interaction with the first contact partners after systemic administration ...
