Compliance Officer
Das Augsburger Qualifizierungsmodell
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Open AccessA Density-Dependent Target Stimulus for Inverse Bone (Re)modeling with Homogenized Finite Element Models
Inverse bone (re)modeling (IBR) can infer physiological loading conditions from the bone microstructure. IBR scales unit loads, imposed on finite element (FE) models of a bone, such that the trabecular microst...
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Open AccessLRP2 contributes to planar cell polarity-dependent coordination of motile cilia function
Motile cilia are protruding organelles on specialized epithelia that beat in a synchronous fashion to propel extracellular fluids. Coordination and orientation of cilia beating on individual cells and across t...
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Open AccessSingle-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury
Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely unders...
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Open AccessDisease relevance of rare VPS13B missense variants for neurodevelopmental Cohen syndrome
Autosomal recessive Cohen syndrome is a neurodevelopmental disorder characterized by postnatal microcephaly, intellectual disability, and a typical facial gestalt. Genetic variants in VPS13B have been found to ca...
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Open AccessA computational framework for canonical holistic morphometric analysis of trabecular bone
Bone is a remarkable, living tissue that functionally adapts to external loading. Therefore, bone shape and internal structure carry information relevant to many disciplines, including medicine, forensic scien...
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Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection
Kidney damage varies according to the primary insult. Different aetiologies of acute kidney injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis, are associated with charac...
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Open AccessCaveolin 1 Promotes Renal Water and Salt Reabsorption
Caveolin-1 (Cav1) is essential for the formation of caveolae. Little is known about their functional role in the kidney. We tested the hypothesis that caveolae modulate renal salt and water reabsorption. Wild-...
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From tubular sublimate nephropathy via urinary concentrating mechanism to glomerular disease—Wilhelm Kriz’s contribution to modern nephrology
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Regulation of renal Na-(K)-Cl cotransporters by vasopressin
Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin receptors (V2R) expressed along...
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Relating surface-enhanced Raman scattering signals of cells to gold nanoparticle aggregation as determined by LA-ICP-MS micromap**
The cellular response to nanoparticle exposure is essential in various contexts, especially in nanotoxicity and nanomedicine. Here, 14-nm gold nanoparticles in 3T3 fibroblast cells are investigated in a series...
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Compliance als interdisziplinäre Herausforderung – Das Augsburger Qualifizierungsmodell
Der Begriff Compliance hat in den letzten Jahren einen einmaligen Siegeszug durch wirtschaftliche und rechtliche Fachkreise angetreten. Dabei haben sich unterschiedliche Definitionen mit verschiedenen Schwerpu...
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The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
Calcineurin inhibitors, such as tacrolimus, are widely used immunosuppressive agents, but they can cause hypertension. In studies of tacrolimus-treated mice, the authors show that hypertension is due to activa...
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Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes
The newly discovered proteins hemojuvelin (Hjv) and transferrin receptor type 2 (TfR2) are involved in iron metabolism. Mutations in the Hjv and TfR2 gene cause hemochromatosis. We investigated the expression ...
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Renal and endocrine changes in rats with inherited stress-induced arterial hypertension (ISIAH)
Hypertensive inbred rats (ISIAH; inherited stress-induced arterial hypertension) present with baseline hypertension (>170 mmHg in adult rats), but attain substantially higher values upon mild emotional stress....
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Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys
Hypothyroidism causes major changes in the kidney by affecting its growth, structure, function, and biosynthesis of its specific gene products. As a consequence, the nephron shows a selective hypotrophy in the...
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Histology, Cytology, Ultrastructure Nephron and Collecting Duct Structure in the Kidney, Rat
The rat kidney is unipapillary. In histologic sections, the different regions of this kidney are well discernible, since both the tubules and the blood vessels are arranged in a regular zonal pattern. The rena...
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Distribution of NOSs in the Kidney
A variety of renal cell types are capable of synthesizing nitric oxide (NO). Three isoforms have been identified to date. There are the constitutive isoforms NOS I also termed neurona I (n) or brain (b) type N...
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Increased expression of nitric oxide synthase in a subpopulation of rat sympathetic neurons after axotomy – correlation with vasoactive intestinal peptide
Nitric oxide synthase (NOS) expression is increased in peripheral sensory and central motor neurons after axotomy. By applying double-labelling immunofluorescence and non-radioactive in situ hybridization, we ...
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Receptor Detection
Receptors for hormones and neurotransmitters can be histochemically detected along their biosynthetic pathway. This may extend from intranuclear transcription and splicing of mRNA to the cytoplasmatic translat...
