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Article
Neural Autoantibody Profile of Primary Achalasia
The etiology and pathogenesis of primary achalasia are both unknown. Postulated mechanisms include autoimmune, viral-immune, and central neurodegenerative. The aim of this study is to investigate the serum pro...
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Article
Neural Autoantibody Evaluation in Functional Gastrointestinal Disorders: A Population-Based Case–Control Study
Our goal is to investigate the serum profile of neural autoantibodies in community-based patients with irritable bowel syndrome (IBS) or functional dyspepsia. The pathogenesis of functional gastrointestinal (G...
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Article
Paraneoplastic encephalomyelopathies: pathology and mechanisms
The last three decades have seen major advances in the understanding of paraneoplastic and idiopathic autoimmune disorders affecting the central nervous system (CNS). Neural-specific autoantibodies and their t...
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Article
NMO spectrum disorders: clinical or molecular classification?
A recent study that applied new criteria for diagnosing neuromyelitis optica spectrum disorders in the absence of serum aquaporin 4 antibodies highlights difficulties with clinical application of these criteri...
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Article
Autoimmune Encephalitis in the ICU: Analysis of Phenotypes, Serologic Findings, and Outcomes
To report the clinical and laboratory characteristics, clinical courses, and outcomes of Mayo Clinic, Rochester, MN, ICU-managed autoimmune encephalitis patients (January 1st 2003–December 31st 2012).
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Article
Open AccessPathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica
Pathogenic autoantibodies associated with neuromyelitis optica (NMO) induce disease by targeting aquaporin-4 (AQP4) water channels enriched on astrocytic endfeet at blood–brain interfaces. AQP4 is also express...
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Article
Breast cancer-related paraneoplastic neurologic disease
Paraneoplastic neurologic disease (PND) is an aberrant immune-mediated response against the nervous system triggered by malignancy. Given the rarity, a paucity of data describing breast cancer-related PND (BC-...
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Article
MRI findings in glutamic acid decarboxylase associated autoimmune epilepsy
Glutamic acid decarboxylase (GAD65) has been implicated in a number of autoimmune-associated neurologic syndromes, including autoimmune epilepsy. This study categorizes the spectrum of MRI findings in patients...
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Article
Open AccessGAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies
Autoantibodies against the smaller isoform of glutamate decarboxylase (GAD65Ab) reflect autoimmune etiologies in Type 1 diabetes (T1D) and several neurological disorders, including Stiff Person Syndrome (SPS)....
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Paraneoplastic Neurologic Disease
Paraneoplastic neurologic disease (PND) is characterized by an aberrant immune-mediated response against the nervous system in the context of an underlying malignancy. Certain malignancies are more notorious f...
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Article
Open AccessThe pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody
We sought to define the pathological features of myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders (MOGAD) in an archival autopsy/biopsy cohort. We histopathologically analyzed 2 autopsie...
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Article
Use of diffusion-weighted imaging to distinguish seizure-related change from limbic encephalitis
To determine whether diffusion-weighted imaging (DWI) can help differentiate peri-ictal signal abnormality from limbic encephalitis (LE) among patients with medial temporal lobe T2-hyperintensity.
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Article
Hope for patients with neuromyelitis optica spectrum disorders — from mechanisms to trials
Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory CNS disease that primarily manifests as relapsing episodes of severe optic neuritis and myelitis. Diagnosis of NMOSD is supported by the de...
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Article
Open AccessNetwork Meta-analysis of Food and Drug Administration-approved Treatment Options for Adults with Aquaporin-4 Immunoglobulin G-positive Neuromyelitis Optica Spectrum Disorder
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease defined by attacks on the central nervous system that cause irreversible damage. Recent approval of NMOSD therapies warrants investigatio...
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Article
Anti-complement Agents for Autoimmune Neurological Disease
In recent years, there has been increasing recognition of the diversity of autoimmune neurological diseases affecting all levels of the nervous system. A growing understanding of disease pathogenesis has enabl...
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Article
Open AccessA Response to: Letter to the Editor Regarding “Network Meta-analysis of Food and Drug Administration-approved Treatment Options for Adults with Aquaporin-4 Immunoglobulin G-positive Neuromyelitis Optica Spectrum Disorder”
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Article
Open AccessObesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis
Optic neuritis (ON) is a frequent presentation at onset of multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). ...
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Open AccessAuthor Correction: Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis
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Article
Sleep disturbances associated with DPPX autoantibodies: a case series
To describe a case series of patients with prominent sleep disturbances and their polysomnography findings in six patients with dipeptidyl-peptidase-like protein-6 (DPPX) autoimmunity syndrome.
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Article
Open AccessEculizumab for the treatment of glycine receptor antibody associated stiff-person syndrome