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Article
Donor-Derived Cell-Free DNA for Acute Rejection Monitoring in Heart and Lung Transplantation
Acute allograft rejection is a common cause of morbidity and mortality in heart and lung transplantation. Unfortunately, the current monitoring gold standard—biopsy plus histopathology—has several limitations....
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Article
De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
The utility of autologous induced pluripotent stem cell (iPSC) therapies for tissue regeneration depends on reliable production of immunologically silent functional iPSC derivatives. However, rejection of auto...
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Article
Open AccessSingle-stranded DNA library preparation uncovers the origin and diversity of ultrashort cell-free DNA in plasma
Circulating cell-free DNA (cfDNA) is emerging as a powerful monitoring tool in cancer, pregnancy and organ transplantation. Nucleosomal DNA, the predominant form of plasma cfDNA, can be adapted for sequencing ...
