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Open AccessEx-situ generation and synthetic utilization of bare trifluoromethyl anion in flow via rapid biphasic mixing
Fluoroform (CF3H) is the simplest reagent for nucleophilic trifluoromethylation intermediated by trifluoromethyl anion (CF3–). However, it has been well-known that CF3– should be generated in presence of a stabil...
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Open AccessFlow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening
The development of miniaturized flow platforms would enable efficient and selective synthesis of drug and lead molecules by rapidly exploring synthetic methodologies and screening for optimal conditions, progr...
