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Article
Author Correction: HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription
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Article
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription
The fetal-to-adult switch in hemoglobin production is a model of developmental gene control with relevance to the treatment of hemoglobinopathies. The expression of transcription factor BCL11A, which represses...
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Article
Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
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Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
The mechanisms by which the fetal-type β-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells remain a fundamental question in human biology and have therapeutic relevance to sickle cel...
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Article
Open AccessHistone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis
Condensation of chromatin prior to enucleation is an essential component of terminal erythroid maturation, and defects in this process are associated with inefficient erythropoiesis and anemia. However, the me...
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Article
Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival
Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor that regulates adipogenesis, immunity and inflammation. Our laboratory previously demonstrated that PPARγ liga...
