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  1. Article

    Open Access

    LRIG1 controls proliferation of adult neural stem cells by facilitating TGFβ and BMP signalling pathways

    Adult Neural Stem Cells (aNSCs) in the ventricular-subventricular zone (V-SVZ) are largely quiescent. Here, we characterize the mechanism underlying the functional role of a cell-signalling inhibitory protein,...

    Stephanie Ouzikov, Kyshona M. Edwards, Tanvi Anandampillai… in Communications Biology (2024)

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  2. Article

    Open Access

    Integrating single-cell and spatially resolved transcriptomic strategies to survey the astrocyte response to stroke in male mice

    Astrocytes, a type of glial cell in the central nervous system (CNS), adopt diverse states in response to injury that are influenced by their location relative to the insult. Here, we describe a platform for s...

    Erica Y. Scott, Nickie Safarian, Daniela Lozano Casasbuenas… in Nature Communications (2024)

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    Article

    Culture Protocol and Transcriptomic Analysis of Murine SVZ NPCs and OPCs

    The mammalian adult brain contains two neural stem and precursor (NPC) niches: the subventricular zone [SVZ] lining the lateral ventricles and the subgranular zone [SGZ] in the hippocampus. From these, SVZ NP...

    Nicole L. Dittmann, Pouria Torabi, Adrianne E. S. Watson… in Stem Cell Reviews and Reports (2023)

  4. No Access

    Protocol

    Production of O-GlcNAc Modified Recombinant Tau in E. coli and Detection of Ser400 O-GlcNAc Tau In Vivo

    Assembly of the microtubule-associated protein tau (tau) into paired helical filaments that ultimately give rise to neurofibrillary tangles (NFTs) makes up one half of the two hallmark pathologies of Alzheimer...

    Scott A. Yuzwa, David J. Vocadlo in Tau Protein (2017)

  5. Article

    Open Access

    Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

    Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmarks of Alzheimer’s disease (AD). Increasing the quantity of the O-linked N-acetylglucosamine (O-GlcNAc) post-translational mo...

    Scott A Yuzwa, **aoyang Shan, Bryan A Jones, Gang Zhao… in Molecular Neurodegeneration (2014)

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  6. No Access

    Article

    Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

    A compound that inhibits hydrolysis of O-GlcNAc groups decreases the neurodegenerative capacity of tau, a protein that forms neurofibrillary tangles in Alzheimer's disease. ...

    Scott A Yuzwa, **aoyang Shan, Matthew S Macauley, Thomas Clark… in Nature Chemical Biology (2012)

  7. No Access

    Article

    Map** O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

    The microtubule-associated protein tau is known to be post-translationally modified by the addition of N-acetyl-d-glucosamine monosaccharides to certain serine and threonine residues. These O-GlcNAc modification ...

    Scott A. Yuzwa, Anuj K. Yadav, Yuliya Skorobogatko, Thomas Clark… in Amino Acids (2011)

  8. No Access

    Article

    A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

    Scott A Yuzwa, Matthew S Macauley, Julia E Heinonen… in Nature Chemical Biology (2008)