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  1. Article

    Open Access

    Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing

    Whole genome next generation sequencing (NGS) is increasingly employed to detect genomic rearrangements in cancer genomes, especially in lymphoid malignancies. We recently established a unique mouse model by s...

    Zhangguo Chen, Katherine Gowan, Sonia M. Leach, Sawanee S. Viboolsittiseri… in BMC Genomics (2016)

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  2. Article

    Open Access

    Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity

    Activated B lymphocytes harbor programmed DNA double-strand breaks (DSBs) initiated by activation-induced deaminase (AID) and repaired by non-homologous end-joining (NHEJ). While it has been proposed that thes...

    Zhangguo Chen, Mihret T. Elos… in Journal of Hematology & Oncology (2016)

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