-
Article
Open AccessIn vitro comparison of the leakage of carbon dioxide and iodine contrast media in a bleeding model
We aimed to compare the hydrodynamic values of carbon dioxide (CO2) and iodine contrast media for bleeding detection using an in vitro model.
-
Article
Continuous microwave-assisted step-by-step extraction of bioactive water-soluble materials and fucoidan from brown seaweed Undaria pinnatifida waste
Continuous extraction production process by microwave-assisted extraction (MAE) using brown macroalgae Undaria pinnatifida waste was investigated to obtain proteins and a sulfated polysaccharide, fucoidan, at low...
-
Article
Open AccessMachine learning using clinical data at baseline predicts the medium-term efficacy of ustekinumab in patients with ulcerative colitis
Predicting the therapeutic response to biologics before administration is a key clinical challenge in ulcerative colitis (UC). We previously reported a model for predicting the efficacy of vedolizumab (VDZ) fo...
-
Article
Open AccessAnxiety and behavioral changes in Japanese patients with inflammatory bowel disease due to COVID-19 pandemic: a national survey
Given the increasing health concerns for patients with inflammatory bowel disease (IBD), amidst the COVID-19 pandemic, we investigated the impact of the pandemic on the anxiety and behavioral changes in Japane...
-
Article
Open AccessEffect of disease duration on fecal biomarkers in ulcerative colitis: a prospective cohort study
Biomarkers such as fecal calprotectin (FC) and fecal immunochemical occult blood tests (FIT) for ulcerative colitis (UC) are used in clinical practice. In this study, the effect of UC disease duration on FC wa...
-
Article
Open AccessModified method of patency judgement using patency capsule prior to capsule endoscopy in clinical practice
In 2012, Japan approved the use of a tag-less patency capsule (PC), which evaluates gastrointestinal patency before small-bowel capsule endoscopy (SBCE). This study aimed to evaluate the validity of our modifi...
-
Article
Open AccessLymphocyte to monocyte ratio and serum albumin changes predict tacrolimus therapy outcomes in patients with ulcerative colitis
Tacrolimus therapy for ulcerative colitis is ineffective in certain patients; these patients require biologics or colectomy. We examined the ability of serum albumin levels and leukocyte subtypes to predict th...
-
Article
Open AccessReal-World Efficacy and Safety Monitoring for Predicting Continuation of Tofacitinib Therapy in Patients with Ulcerative Colitis
Although the clinical efficacy of tofacitinib in patients with ulcerative colitis (UC) has been assessed in the OCTAVE trial, there is a lack of adequate data on its efficacy in real-world clinical settings.
-
Article
Influence of daily versus alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel
Vonoprazan, a potassium-competitive acid blocker, inhibits gastric acid secretion and attenuates the antiplatelet function of clopidogrel more potently than esomeprazole. We investigated whether alternate-day ...
-
Article
Open AccessFurther research on the clinical relevance of the ulcerative colitis colonoscopic index of severity for predicting 5-year relapse
The ulcerative colitis colonoscopic index of severity (UCCIS) evaluates the state of the entire colonic mucosa in ulcerative colitis. However, no cut-off values of scores for predicting clinical relapse in pat...
-
Article
Open AccessMachine learning using clinical data at baseline predicts the efficacy of vedolizumab at week 22 in patients with ulcerative colitis
Predicting the response of patients with ulcerative colitis (UC) to a biologic such as vedolizumab (VDZ) before administration is an unmet need for optimizing individual patient treatment. We hypothesized that...
-
Article
Open AccessComparison between Prostaglandin E-major urinary metabolite and C-reactive protein levels to reflect endoscopic scores in patients with ulcerative colitis
Prostaglandin E-major urinary metabolite (PGE-MUM) and C-reactive protein (CRP) are useful biomarkers in patients with ulcerative colitis. However, whether changes in endoscopic scores over time are reflected ...
-
Article
Open AccessTranscatheter arterial embolization for severe blunt liver injury in hemodynamically unstable patients: a 15-year retrospective study
Transcatheter arterial embolization (TAE) is the first-line nonsurgical treatment for severe blunt liver injury in patients, whereas operative management (OM) is recommended for hemodynamically unstable patien...
-
Article
Open AccessPrevalence of UL97 gene mutations and polymorphisms in cytomegalovirus infection in the colon associated with or without ulcerative colitis
Cytomegalovirus (CMV) reactivation in the colon is common in patients with severe ulcerative colitis (UC). Ganciclovir (GCV) resistance conferring CMV UL97 gene mutations have been reported in recent years. Ho...
-
Article
Open AccessC-reactive protein is superior to fecal biomarkers for evaluating colon-wide active inflammation in ulcerative colitis
We evaluated the association between endoscopic scores of colonic inflammation and fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP) in patients with ulcerativ...
-
Chapter and Conference Paper
Using Deep-Learning Approach to Detect Anomalous Vibrations of Press Working Machine
In recent years, there has been a demand for advanced maintenance in factories. Data collection from factory equipment is being carried out, and the collected sensor data is widely used for statistical analysi...
-
Article
Open AccessMesalazine granule formulation improves clinical data in Crohn's disease compared with tablet formulation
The efficacy of sustained-release preparations of mesalazine as a remission maintenance treatment for Crohn's disease remains to be established. We aimed to examine the changes in compliance rate and clinical ...
-
Article
Effect of ulcerative colitis duration on the usefulness of immunochemical fecal occult blood test result as a disease activity biomarker
The effects of ulcerative colitis (UC) duration on biomarker accuracy are unknown. We investigated the effects of UC duration on the predictive accuracy of biomarkers including immunochemical fecal occult bloo...
-
Article
Open AccessProstaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis
Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blo...
-
Chapter and Conference Paper
Vibration Characteristics of Self-excited Vibration About Sliding Bearings
This paper shows vibration characteristics of a sliding bearings. Especially, we study self-excited vibration (Oil whirl) of the sliding bearings. We tried three analysis methods, which are trajectory of shaft...
