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Article
Open AccessHydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage
Molecular hydrogen (H2) protect neurons against reactive oxygen species and ameliorates early brain injury (EBI) after subarachnoid hemorrhage (SAH). This study investigated the effect of H2 on delayed brain inju...
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Article
Open AccessFacile synthesis and nanoscale features of a nanostructured nordihydroguaiaretic acid analog for therapeutic applications
Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, known to possess anti-oxidant, anti-cancer and anti-viral activities and is being used in traditional medicine. However, toxicity...
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Chapter and Conference Paper
Modified Extradural Temporopolar Approach for Paraclinoid Aneurysms: Operative Nuance and Surgical Result
Background. Extradural temporopolar approach can provide extensive exposure of the anterior clinoid process, which can prevent intraoperative neurovascular injury in anterior clinoidectomy for paraclinoid aneurys...
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Article
De novo formation and rupture of proximal anterior cerebral artery aneurysm associated with middle cerebral artery occlusion
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Article
Open AccessHydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats
Enhanced oxidative stress occurs in spontaneously hypertensive stroke-prone rats (SHRSP), and is important in blood–brain barrier (BBB) disruption. Hydrogen can exert potent protective cellular effects via red...
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Article
Open AccessEffects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial
The failures of recent studies intended to prevent cerebral vasospasm have moved the focus of research into delayed cerebral ischemia away from cerebral artery constriction towards other mechanisms. Recent acc...
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Article
Localized Neurofibromas in the Bilateral Orbits
Localized neurofibromas are rare in the orbit and, unlike the more common plexiform neurofibromas, are not typically associated with von Recklinghausen neurofibromatosis. We present a rare case of localized ne...
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Article
Open AccessSafety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
Most of the results regarding hydrogen (H2) therapy for acute cerebral ischemia are derived from in vitro studies and animal experiments, with only a few obtained from human trials with a limited number of subjec...
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Chapter and Conference Paper
A Suitable Formula for Estimating the Volume Gained by Decompressive Craniectomy in Malignant Hemispheric Infarction
Decompressive craniectomy (DC) improves the survivability and functional outcome in patients with malignant hemispheric infarction (MHI). The decompressive effect of DC depends on the decompressive volume (DV)...
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Chapter and Conference Paper
Traumatic Hematoma of the Posterior Fossa
Posterior fossa injury is rare, occurring in less than 3 % of head injuries. We retrospectively reviewed patients’ clinical and radiological findings, management, and outcomes. The aim of the present study was...
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Chapter and Conference Paper
Subacute Subdural Hematoma
Subacute subdural hematoma (SASDH) is a rare entity. We retrospectively reviewed 8 patients with SASDH. Four patients were male and 4 were female, with an age range of 45–87 years (mean, 67.8 years). The minim...
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Chapter and Conference Paper
Evaluation of the Stage of Hemorrhage Using Optical Diffuse Reflectance Spectroscopy: An In Vivo Study
Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke. Estimation of the stage of hemorrhage allows clinicians to know when the hemorrhage occurred, even in unconscious patients, enablin...
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Chapter and Conference Paper
Cerebrospinal Fluid Congestion in the Perioptic Space
Recent attention has been paid to the cerebrospinal fluid (CSF) dynamics between the intracranial subarachnoid space (SAS) and the SAS around the optic nerve (ON-SAS). We experienced three patients who had an...
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Chapter and Conference Paper
Computed Tomography After Decompressive Craniectomy for Head Injury
New findings (NF) on postoperative CTs are occasionally found in patients who undergo surgery for traumatic brain injury (TBI). We conducted a retrospective registry-based review of the care of 102 patients ...
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Chapter and Conference Paper
Is Decompressive Craniectomy a Risk Factor for Ventriculomegaly?
Objective: Decompressive craniectomy (DC) is an established therapeutic option following severe traumatic brain injury (TBI). However, several delayed complications of DC have been reported, includ...
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Chapter and Conference Paper
A Better Mild Traumatic Brain Injury Model in the Rat
The primary pathology associated with mild traumatic brain injury (TBI) is selective axonal injury, which may characterize the vast majority of blast-induced TBIs. Axonal injuries in cases of mild TBI have be...
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Chapter and Conference Paper
Hydrocephalus Following Decompressive Craniectomy for Ischemic Stroke
Numerous studies on hydrocephalus after decompressive craniectomy (DC) for severe traumatic brain injury have been reported, whereas there have been only two reports on DC for hemispheric cerebral infarction. ...
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Chapter and Conference Paper
Adiponectin and Traumatic Brain Injury
Adiponectin, a circulating adipose-derived hormone regulating inflammation and energy metabolism, has beneficial actions on cardiovascular disorders. Recent studies have suggested that adiponectin might be a p...
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Chapter and Conference Paper
Traumatic Basal Ganglia Hematomas: An Analysis of 20 Cases
Twenty patients with traumatic basal ganglia hematoma (TBGH) were studied. Of the 20 patients, 16 were male and 4 were female, with an age range of 4–89 years (mean, 54.4 years). The causes of injury were traf...
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Chapter and Conference Paper
The Effect of Hydrogen Gas on a Mouse Bilateral Common Carotid Artery Occlusion
In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of th...
