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Article

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

Amyloid-β peptide ending at 42nd residue (Aβ42) is believed as a pathogenic peptide for Alzheimer disease. Although γ-secretase is a responsible protease to generate Aβ through a processive cleavage, the prote...

Yu Ohki, Naoaki Shimada, Aya Tominaga, Satoko Osawa… in Molecular Neurodegeneration (2014)