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Article
Open AccessA multicenter case registry study on medication-related osteonecrosis of the jaw in patients with advanced cancer
This observational case registry study was designed to describe the natural history of cancer patients with medication-related osteonecrosis of the jaw (ONJ) and evaluate the ONJ resolution rate.
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Article
Open AccessA first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia
Hepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow t...
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Article
Delaying skeletal-related events in a randomized phase 3 study of denosumab versus zoledronic acid in patients with advanced cancer: an analysis of data from patients with solid tumors
Bone complications of metastatic disease, including skeletal-related events (SREs), impair patients' functioning and quality of life. In a randomized, phase 3 trial of 1,776 patients with metastases from solid...
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Article
Open AccessAnalysis of Aurora kinase A expression in CD34+ blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia
Aurora kinase A, also known as aurora A, is a serine/threonine kinase that plays critical roles in mitosis entry, chromosome alignment, segregation, and cytokinesis. Overexpression of aurora A has been observe...
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Article
Open AccessCytokines, GM-CSF and IFNγ administered by priming and post-chemotherapy cycling in recurrent ovarian cancer patients receiving carboplatin
Monocyte/macrophages (MO/MA), a polymorphic population of innate immune cells, have the potential to mediate antitumor effects, and may also contribute to protumor effects. A priming and post-chemotherapy sche...
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Article
The effects of interleukin-1 therapy on peripheral blood granulocyte function in humans
During a phase I trial of interleukin-1α (IL-1α) in patients with ovarian carcinomas, the effects of this treatment on blood granulocyte respiratory burst and locomotive responses were examined. Differences in...
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Article
Preclinical and clinical studies with the hematopoietic colony-stimulating factors and related interleukins
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Article
The Effects of Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor on in Vitro Cord Blood Granulocyte Function
ABSTRACT: Neonatal granulocytes are recognized to have functional defects which are thought to be important in the increased susceptibility to infection in the neonate. Recombinant human granulocyte-macrophage...
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Preclinical and Clinical Effects of the Hematopoietic Colony Stimulating Factors
Hematopoietic colony stimulating factors are available in purified recombinant form and have used for assessment of hematopoietic activities in mice, monkeys and in phase I clinical trials with humans. This re...
