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  1. No Access

    Article

    SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

    L1 retrotransposons are an abundant class of transposable elements that pose a threat to genome stability and may have a role in age-related pathologies such as cancer. Recent evidence indicates that L1s becom...

    Michael Van Meter, Mehr Kashyap, Sarallah Rezazadeh… in Nature Communications (2014)

  2. No Access

    Article

    On BLM helicase in recombination-mediated telomere maintenance

    Bloom syndrome (BS) is an extremely rare, autosomal recessive genetic syndrome of humans. Patients with BS are predisposed to almost all forms of cancer and also display premature aging phenotypes. These patie...

    Sarallah Rezazadeh in Molecular Biology Reports (2013)

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    Article

    RecQ helicases; at the crossroad of genome replication, repair, and recombination

    DNA helicases are ubiquitous enzymes that unwind double-stranded DNA in an ATP-dependent and directionally specific manner. Such an action is essential for the processes of DNA repair, recombination, transcrip...

    Sarallah Rezazadeh in Molecular Biology Reports (2012)