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Chapter and Conference Paper
Pilot Study for Myoelectric Control of a Supernumerary Robot During a Coordination Task
Robots are used in a wide variety of applications to augment the capability of humans. A relatively new category of assistive robots, supernumerary robots (SRs), create an additional, kinematically independent...
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Chapter and Conference Paper
Effectiveness of Self-customized Refresher and Just-In-Time-Training for Mechanical Repair Task Performance
Future space exploration missions are expected to increase in duration with timelines as long as three years. Applying the current training paradigm to support longer duration missions reveals a substantial sk...
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Chapter and Conference Paper
Methodology to Quantify Accuracy for Procedure Execution Analysis
Several industries have sought to identify, mitigate, and predict human errors, as human errors contribute to accidents. We present a new methodology, Procedure Deviation Analysis (PDA), which establishes a hu...
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Article
Author Correction: The evolutionary history of lethal metastatic prostate cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessAugmented exercise in hospital improves physical performance and reduces negative post hospitalization events: a randomized controlled trial
To measure the effects of an augmented prescribed exercise programme versus usual care, on physical performance, quality of life and healthcare utilisation for frail older medical patients in the acute setting.
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Article
Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences
In the Methods section of this Article, ‘greater than’ should have been ‘less than’ in the sentence ‘Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distan...
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Article
Open AccessAnalysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups
In multiple myeloma, next-generation sequencing (NGS) has expanded our knowledge of genomic lesions, and highlighted a dynamic and heterogeneous composition of the tumor. Here we used NGS to characterize the g...
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Article
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
Whole-genome sequencing of normal blood cells sampled from 241 adults is used to infer mosaic point mutations that are likely to have arisen during early embryogenesis, providing insight into how early cellula...
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Article
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93...
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Article
Open AccessA study protocol of a randomised controlled trial to measure the effects of an augmented prescribed exercise programme (APEP) for frail older medical patients in the acute setting
Older adults experience functional decline in hospital leading to increased healthcare burden and morbidity. The benefits of augmented exercise in hospital remain uncertain. The aim of this trial is to measure...
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Article
At the very heart of progress
The ambition driving China's astonishing progress in the output of high-quality science is particularly strong in some cities, whose growth far outstrips expectation.
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Article
Correction: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
Nat. Genet. 47, 367–372 (2015); published online 2 March 2015; corrected after print 5 May 2015 In the version of this article initially published, author Manasa Ramakrishna was omitted from the author list. T...
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Article
Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue
Colin Cooper and colleagues report genome-wide sequences of multiple samples of multifocal cancer and morphologically normal tissue from the prostates of three men. They found high levels of mutations in morph...
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Article
The evolutionary history of lethal metastatic prostate cancer
The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees behind the development and spread of these cancers...
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Article
Open AccessPolygenic in vivovalidation of cancer mutations using transposons
The in vivo validation of cancer mutations and genes identified in cancer genomics is resource-intensive because of the low throughput of animal experiments. We describe a mouse model that allows multiple cancer ...
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Article
Open AccessProcessed pseudogenes acquired somatically during cancer development
Cancer evolves by mutation, with somatic reactivation of retrotransposons being one such mutational process. Germline retrotransposition can cause processed pseudogenes, but whether this occurs somatically has...
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Article
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia
Peter Campbell, Mel Greaves and colleagues use exome and whole-genome sequencing to characterize somatic mutations in childhood acute lymphoblastic leukemias with the ETV6-RUNX1 fusion gene. They find that RAG-me...
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Article
Open AccessHeterogeneity of genomic evolution and mutational profiles in multiple myeloma
Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number profiling and cytogenetics to analyse ...
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Article
Open AccessThe genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models
Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even...
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Article
Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma
Andrew Futreal and colleagues identify the major cartilage collagen gene COL2A1 as a frequent target of somatic mutation in chondrosarcoma. The mutation patterns are consistent with selection for variants likely ...
