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Article
Open AccessCan multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?
Several single nucleotide polymorphisms (SNPs) at different loci have been associated with breast cancer susceptibility, accounting for around 10% of the familial component. Recent studies have found direct as...
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Article
Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral
The aim of this study was to establish if risk-reducing surgery (RRS) increases survival among BRCA1/2 carriers without breast/ovarian cancer at the time of family referral. Female BRCA1/2 carriers were identifie...
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Article
Contralateral mastectomy improves survival in women with BRCA1/2-associated breast cancer
BRCA1/2 mutation carriers with breast cancer are at high risk of contralateral disease. Such women often elect to have contralateral risk-reducing mastectomy (CRRM) to reduce the likelihood of re...
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Article
Contralateral breast cancer risk in BRCA1/2-positive families needs to be adjusted for phenocopy rates particularly in second-degree untested relatives
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Article
Open AccessDevelopment and validation of self-reported line drawings for assessment of knee malalignment and foot rotation: a cross-sectional comparative study
For large scale epidemiological studies clinical assessments and radiographs can be impractical and expensive to apply to more than just a sample of the population examined. The study objectives were to develo...
