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  1. Article

    Open Access

    Transcriptomics of type 2 diabetic and healthy human neutrophils

    Chronic inflammatory diseases, including diabetes and cardiovascular disease, are heterogeneous and often co-morbid, with increasing global prevalence. Uncontrolled type 2 diabetes (T2D) can result in severe i...

    Sarah E. Kleinstein, Jamison McCorrison, Alaa Ahmed, Hatice Hasturk… in BMC Immunology (2021)

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    Article

    Genome-wide association study (GWAS) of human host factors influencing viral severity of herpes simplex virus type 2 (HSV-2)

    Herpes simplex virus type 2 (HSV-2) is an incurable viral infection with severity ranging from asymptomatic to frequent recurrences. The viral shedding rate has been shown as a reproducible HSV-2 severity end ...

    Sarah E. Kleinstein, Patrick R. Shea, Andrew S. Allen, David M. Koelle… in Genes & Immunity (2019)

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    Article

    COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations

    Nonsteroidal anti-inflammatory drugs (NSAIDs) target the prostaglandin H synthase enzymes, cyclooxygenase (COX)-1 and COX-2, and reduce colorectal cancer risk. Genetic variation in the genes encoding these enz...

    Karen W. Makar, Elizabeth M. Poole, Alexa J. Resler… in Cancer Causes & Control (2013)