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Article
The Kinase Fyn As a Novel Intermediate in l-DOPA-Induced Dyskinesia in Parkinson’s Disease
Dopamine replacement therapy with l-DOPA is the treatment of choice for Parkinson’s disease; however, its long-term use is frequently associated with l-DOPA-induced dyskinesia (LID). Many molecules have been impl...
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Article
Open AccessElevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer’s disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent...
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Article
Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells
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Reference Work Entry In depth
Concept of Excitotoxicity via Glutamate Receptors
Since its inception, the concept of glutamate excitotoxicity has provided a foundational framework for understanding the role played by excitatory amino acids in disease states of the brain. At the same time, ...
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Protocol
Study of Neurotoxic Intracellular Calcium Signalling Triggered by Amyloids
Neurotoxicity in Alzheimer’s disease (AD) is associated to dishomeostasis of intracellular Ca2+ induced by amyloid β peptide (Aβ) species. Understanding of the effects of Aβ on intracellular Ca2+ homeostasis requ...
