-
Article
Open AccessTranslation of upstream open reading frames in a model of neuronal differentiation
Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside. Ribosome profiling ...
-
Article
Open AccessSPECtre: a spectral coherence-based classifier of actively translated transcripts from ribosome profiling sequence data
Active protein translation can be assessed and measured using ribosome profiling sequencing strategies. Prevailing analytical approaches applied to this technology make use of sequence fragment length profilin...
-
Article
The mutational landscape of lethal castration-resistant prostate cancer
Exome sequencing is used to investigate the role of mutations and copy number aberrations in metastatic castration-resistant prostate cancer, revealing recurrent mutations in multiple chromatin/histone modifyi...
-
Article
Open AccessOncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes
Activating KRAS mutations are important for cancer initiation and progression; and have recently been shown to cause primary resistance to therapies targeting the epidermal growth factor receptor. Therefore, stra...
