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Chapter
The receptor binding domain of apolipoprotein E, linked to a model class A amphipathic helix, enhances internalization and degradation of LDL in fibroblasts
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Chapter
Atherogenicity of Triglyceride-Rich Lipoproteins: Cellular Aspects
Abnormal triglyceride-rich lipoproteins (TGRLP) are found in many fasting hypertriglyceridemia (HTG) subjects and postprandially in subjects with profiles associated with cardiovascular risk (elevated plasma t...
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Chapter and Conference Paper
A Cellular Basis for the Potential Atherogenicity of Triglyceride-Rich Lipoproteins
Two potential intiating events in atherosclerosis are endothelial injury and the accumulation of lipid-filled foam cells in the arterial intima. Ross and Glomset suggested that atherosclerosis may be a respons...
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Article
Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100
Apolipoprotein (apo) B-100, the major protein component in low density lipoprotein (LDL), is the ligand that binds to the LDL receptor1. It is important in the metabolism of LDL and elevated plasma levels of LDL-...
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Article
Abnormal suppression of 3-hydroxy-3-methylglutaryl-CoA reductase activity in cultured human fibroblasts by hypertriglyceridemic very low density lipoprotein subclasses
Our previous studies showed that hypertriglyceridemic very low density lipoproteins (HTG VLDL) are functionally abnormal. HTG VLDL, but not normal VLDL, suppress HMG-CoA reductase in cultured normal human fibr...