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  1. No Access

    Protocol

    Immunohistochemistry for Tumor-Infiltrating Immune Cells After Oncolytic Virotherapy

    Immunohistochemistry (IHC) is an integral laboratory staining technique, which is used for the detection of immune cells in mouse/human tissues or tumors. Oncolytic herpes simplex virus (oHSV) treatment or vir...

    Dipongkor Saha, Samuel D. Rabkin in Oncolytic Viruses (2020)

  2. Article

    Open Access

    Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta

    Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in...

    Jiani Wang, Lihua Xu, Weigen Zeng, Pan Hu, Musheng Zeng… in Cancer Cell International (2014)

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    Chapter

    Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors

    Oncolytic virus therapy is a promising new strategy for treating cancer that involves replication-competent virus vectors that can replicate in situ in tumor cells, exhibit oncolytic activity by direct cytocidal ...

    Tomoki Todo, Samuel D. Rabkin in Cancer Gene Therapy (2005)

  4. No Access

    Article

    Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

    We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells (and o...

    Toshihiro Mineta, Samuel D. Rabkin, Takahito Yazaki, William D. Hunter… in Nature Medicine (1995)