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Article
Open AccessNuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells
During metastatic dissemination, circulating tumour cells (CTCs) enter capillary beds, where they experience mechanical constriction forces. The transient and persistent effects of these forces on CTCs behavio...
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Protocol
Circulating Tumor Cell Cluster Sorting by Size and Asymmetry
Circulating tumor cell (CTC) clusters are rare yet potent initiators of metastasis and may be useful as clinical biomarkers. Numerous techniques have been developed to isolate individual circulating tumor cell...
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Chapter
In Vitro and In Vivo Host Models of Metastasis
Metastasis is a complex multi-step process that typically occurs over years, making the process challenging to accurately model in the laboratory. This chapter explores our existing animal and non-animal host ...
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Article
Open AccessArresting metastasis within the microcirculation
The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells a...
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Article
Open AccessSqueezing through the microcirculation: survival adaptations of circulating tumour cells to seed metastasis
During metastasis, tumour cells navigating the vascular circulatory system—circulating tumour cells (CTCs)—encounter capillary beds, where they start the process of extravasation. Biomechanical constriction fo...
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Article
Open AccessHybrid 3D printed-paper microfluidics
3D printed and paper-based microfluidics are promising formats for applications that require portable miniaturized fluid handling such as point-of-care testing. These two formats deployed in isolation, however...
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Article
Open AccessMicrofluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry
Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although there are numerous devices developed to isolate ind...
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Article
Integrated microbioreactor for culture and analysis of bacteria, algae and yeast
We introduce a micro-scale bioreactor for automated culture and density analysis of microorganisms. The microbioreactor is powered by digital microfluidics (DMF) and because it is used with bacteria, algae and...
